Recombinant Human ICK

• Cat.No.: ICK-28676TH
• Product Overview: Recombinant full length Human ICK with an N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; MWt 98kDa.

Specification

• Description: Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
• Protein length: 632 amino acids
• Molecular Weight: 98.000kDa inclusive of tags
• Source: Baculovirus
• Biological activity: The Specific activity of ICK-28676TH was determined to be 4.8 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: ICK intestinal cell (MAK-like) kinase [ Homo sapiens ]
• Official Symbol: ICK
• Synonyms: ICK; intestinal cell (MAK-like) kinase; serine/threonine-protein kinase ICK; KIAA0936; LCK2; MGC46090; MRK
• Gene ID: 22858
• mRNA Refseq: NM_016513
• Protein Refseq: NP_057597
• MIM: 612325
• Uniprot ID: Q9UPZ9
• Chromosome Location: 6p12.3-p11.2
• Function: ATP binding; cyclin-dependent protein kinase activity; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity