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Recombinant Human Interleukin 11

Cat. No.: IL11-218H
Product Overview: Recombinant Human interleukin 11 DNA sequence encoding the mature 173 ammino acid human IL-11 protein sequence was inserted into a suitable expression vector and was expressed inSf21 insect cellsusing a baculovirus expression system.
Description: Interleukin 11 (IL-11) is a multifunctional cytokine isolated from bone marrow-derived stromal cells. It is a key regulator of multiple events in hemtaopoiesis, most notably the stimulation of megakaryocyte maturation. It is also known under the names Adipogenesis inhibitory factor (AGIF) and Oprelvekin. IL-11 improves platelet recovery after chemotherapy-induced thrombocytopenia, induces acute phase proteins, modulates antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis.
Source: Sf21 Insect Cells.
Molecular Weight: The predicted molecular weight of Recombinant Human IL-11 is Mr 19 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 23 kDa.
State Of Matter: Solution.
Formulation: This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. The final protein concentration is 0.25 mg/ml.
Purity: > 97% by SDS Page and analyzed by silver stain.
Endotoxin: < 0.1 ng per 1 µg as determined by the LAL method.
Biological Activity: The biological activity of Human IL-11 was determined by a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11. The expected ED50 for this effect is typically 0.06 - 0.24 ng/mL.
Storage And Stability: Working aliquots of this recombinant protein solution are stable for up to twelve months at -20˚C to -70˚C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2˚C - 8˚C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20˚C to -70˚C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Gene Name: IL11 interleukin 11 [ Homo sapiens ]
Synonyms: AGIF; IL-11; Adipogenesis inhibitory factor, Oprelvekin, Interleukin-11; IL11; interleukin 11
Gene ID: 3589
mRNA Refseq: NM_000641
Protein Refseq: NP_000632
UniProt ID: P20809
Chromosome Location: 19q13.3-q13.4
MIM: 147681
Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Function: cytokine activity, interleukin-11 receptor binding activity

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