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Recombinant Human LMNA

Cat.No.: LMNA-28297TH
Product Overview: Recombinant full length Human Lamin A, amino acids 1-456, MWt 74 kDa.
Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Source: E. coli
Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle celle (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degener
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Belongs to the intermediate filament family.
Gene Name: LMNA lamin A/C [ Homo sapiens ]
Official Symbol: LMNA
Synonyms: LMNA; lamin A/C; cardiomyopathy, dilated 1A (autosomal dominant) , CMD1A, lamin A/C like 1 , LGMD1B, limb girdle muscular dystrophy 1B (autosomal dominant) , LMN1, LMNL1, PRO1, progeria 1 (Hutchinson Gilford type); prelamin-A/C; HGPS;
Gene ID: 4000
mRNA Refseq: NM_005572
Protein Refseq: NP_005563
MIM: 150330
Uniprot ID: P02545
Chromosome Location: 1q22
Pathway: Activation of Chaperones by IRE1alpha, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function: protein binding; structural molecule activity; structural molecule activity;

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