Recombinant Full Length Human LMNA Protein, C-Flag-tagged
Cat.No. : | LMNA-25HFL |
Product Overview : | Recombinant Full Length Human LMNA Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 74 kDa |
AA Sequence : | METPSQRRATRSGAQASSTPLSPTR ITRLQEKEDLQELNDRLAVYIDRVR SLETENAGLRLRITESEEVV SREVSGIKAAYEAELGDARKTLDSV AKERARLQLELSKVREEFKELKARN TKKEGDLIAAQARLKDLEAL LNSKEAALSTALSEKRTLEGELHDL RGQVAKLEAALGEAKKQLQDEMLRR VDAENRLQTMKEELDFQKNI YSEELRETKRRHETRLVEIDNGKQR EFESRLADALQELRAQHEDQVEQYK KELEKTYSAKLDNARQSAER NSNLVGAAHEELQQSRIRIDSLSAQ LSQLQKQLAAKEAKLRDLEDSLARE RDTSRRLLAEKEREMAEMRA RMQQQLDEYQELLDIKLALDMEIHA YRKLLEGEEERLRLSPSPTSQRSRG RASSHSSQTQGGGSVTKKRK LESTESRSSFSQHARTSGRVAVEEV DEEGKFVRLRNKSNEDQSMGNWQIK RQNGDDPLLTYRFPPKFTLK AGQVVTIWAAGAGATHSPPTDLVWK AQNTWGCGNSLRTALINSTGEEVAM RKLVRSVTVVEDDEDEDGDD LLHHHHGSHCSSSGDPAEYNLRSRT VLCGTCGQPADKASASGSGAQVGGP ISSGSSASSVTVTRSYRSVG GSGGGSFGDNLVTRSYLLGNSSPRT QSPQNCSIMTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
Gene Name : | LMNA lamin A/C [ Homo sapiens (human) ] |
Official Symbol : | LMNA |
Synonyms : | FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B |
Gene ID : | 4000 |
mRNA Refseq : | NM_170707.4 |
Protein Refseq : | NP_733821.1 |
MIM : | 150330 |
UniProt ID : | P02545 |
Products Types
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LMNA-1304H | Recombinant Human LMNA Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
LMNA-4712HCL | Recombinant Human LMNA 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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