Recombinant Human MARK4

• Cat.No.: MARK4-29129TH
• Product Overview: Recombinant full length Human MARK4 with an N terminal proprietary tag, 104kDa.

Specification

• Description: This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimers disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Protein length: 752 amino acids
• Molecular Weight: 104.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Ubiquitous. Isoform 2 is brain-specific.
• Biological activity: The Specific activity of MARK4-29129TH was determined to be 1050 nmol/min/mg.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.Contains 1 KA1 (kinase-associated) domain.Contains 1 protein kinase domain.Contains 1 UBA domain.

Gene Information

• Gene Name: MARK4 MAP/microtubule affinity-regulating kinase 4 [ Homo sapiens ]
• Official Symbol: MARK4
• Synonyms: MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity regulating kinase like 1 , MARKL1; FLJ90097; KIAA1860; Nbla00650
• Gene ID: 57787
• mRNA Refseq: NM_001199867
• Protein Refseq: NP_001186796
• MIM: 606495
• Uniprot ID: Q96L34
• Chromosome Location: 19q13.2
• Pathway: LKB1 signaling events, organism-specific biosystem
• Function: ATP binding; ATP binding; gamma-tubulin binding; microtubule binding; nucleotide binding