Recombinant Human MCM7
Cat.No. : | MCM7-28043TH |
Product Overview : | Recombinant full length Human MCM7 with N terminal proprietary tag; Predicted MWt 68.90 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Protein length : | 389 amino acids |
Molecular Weight : | 68.900kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRL AHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADA VQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR SPQNQYPAELMRRFELYFQGPSSSKPRVIREVRADSVGKL VTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTF MPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPI LRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELT REELRQIADVIFATVRELVSGGRSVRFSEAEQRCVSRGFT PAQFQAALDEYEELNVWQVNASRTRITFV |
Sequence Similarities : | Belongs to the MCM family.Contains 1 MCM domain. |
Gene Name : | MCM7 minichromosome maintenance complex component 7 [ Homo sapiens ] |
Official Symbol : | MCM7 |
Synonyms : | MCM7; minichromosome maintenance complex component 7; MCM2, MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 7; DNA replication licensing factor MCM7; CDC47; |
Gene ID : | 4176 |
mRNA Refseq : | NM_005916 |
Protein Refseq : | NP_005907 |
MIM : | 600592 |
Uniprot ID : | P33993 |
Chromosome Location : | 7q21.3-q22.1 |
Pathway : | Activation of ATR in response to replication stress, organism-specific biosystem; Activation of the pre-replicative complex, organism-specific biosystem; Assembly of the pre-replicative complex, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; |
Function : | ATP binding; contributes_to ATP-dependent DNA helicase activity; contributes_to DNA binding; hydrolase activity; nucleotide binding; |
Products Types
◆ Recombinant Protein | ||
MCM7-4517H | Recombinant Human MCM7 Protein, GST-tagged | +Inquiry |
MCM7-01H | Recombinant Human MCM7 Protein, Myc/DDK-tagged | +Inquiry |
MCM7-1383H | Recombinant Human MCM7 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mcm7-3998M | Recombinant Mouse Mcm7 Protein, Myc/DDK-tagged | +Inquiry |
MCM7-427H | Recombinant Human minichromosome maintenance complex component 7, His-tagged | +Inquiry |
◆ Lysates | ||
MCM7-4415HCL | Recombinant Human MCM7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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