Recombinant Human MLLT4, GST-tagged

• Cat.No.: MLLT4-29200TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-141 of Human l Afadin with GST tag at the N-terminus, predicted MWt 42kDa.

Specification

• Description: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
• Conjugation: GST
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 50mM Sodium chloride, 25mM HEPES, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 dilute domain.Contains 1 FHA domain.Contains 1 PDZ (DHR) domain.Contains 2 Ras-associating domains.

Gene Information

• Gene Name: MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 [ Homo sapiens ]
• Official Symbol: MLLT4
• Synonyms: MLLT4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4; afadin; AF 6; AF6
• Gene ID: 4301
• mRNA Refseq: NM_001040000
• Protein Refseq: NP_001035089
• MIM: 159559
• Uniprot ID: P55196
• Chromosome Location: 6q27
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem
• Function: protein C-terminus binding