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Recombinant Human NTRK1, Fc-tagged

Cat. No. : NTRK1-495H
Product Overview : Recombinant Human NTRK1 encoding the signal peptide from human CD33 joined with the extracellular domain of human Trk A (Ala 33 - Glu 407) was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells.
Description : This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Molecular Weight : The predicted molecular weight of Recombinant Human is Mr 67.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 115-125 kDa.
Source : NSO Cells.
State Of Matter : Lyophilized.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity : >95% by SDS Page and analyzed by silver stain.
Biological Activity : The biological activity of Human TrkA was determined by its ability to inhibit NGF-induced proliferation of TF1 cells. The ED50 for this effect is typically 0.8 - 4 μg/mL in the presence of 10 ng/mL of rhNGF.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
PDB rendering based on 1he7. :

Gene Name : NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ]
Synonyms : NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1; OTTHUMP00000038736; Trk-A; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein
Gene ID : 4914
mRNA Refseq : NM_001007792
Protein Refseq : NP_001007793
MIM : 191315
UniProt ID : P04629
Chromosome Location : 1q21-q22
Pathway : Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF
Function : ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity

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