Recombinant Human NTRK1, Fc-tagged
Cat.No. : | NTRK1-495H |
Product Overview : | Recombinant Human NTRK1 encoding the signal peptide from human CD33 joined with the extracellular domain of human Trk A (Ala 33 - Glu 407) was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | NTRK1-495H |
Description : | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. |
Molecular Weight : | The predicted molecular weight of Recombinant Human is Mr 67.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 115-125 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Formulation : | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Biological Activity : | The biological activity of Human TrkA was determined by its ability to inhibit NGF-induced proliferation of TF1 cells. The ED50 for this effect is typically 0.8 - 4 μg/mL in the presence of 10 ng/mL of rhNGF. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ] |
Synonyms : | NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1; OTTHUMP00000038736; Trk-A; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein |
Gene ID : | 4914 |
mRNA Refseq : | NM_001007792 |
Protein Refseq : | NP_001007793 |
MIM : | 191315 |
UniProt ID : | P04629 |
Chromosome Location : | 1q21-q22 |
Pathway : | Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF |
Function : | ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
NTRK1-01H | Active Recombinant Human NTRK1 Protein (34-407), Animal free | +Inquiry |
Ntrk1-16R | Recombinant Rat Ntrk1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NTRK1-2030H | Recombinant Human NTRK1 Protein, Fc/His-tagged | +Inquiry |
NTRK1-1322C | Acitve Recombinant Canine NTRK1 protein(Pro285-Lys410), hFc-tagged | +Inquiry |
NTRK1-1352R | Acitve Recombinant Rat NTRK1 protein(Met1-Pro418), hFc-tagged | +Inquiry |
◆ Lysates | ||
NTRK1-1086MCL | Recombinant Mouse NTRK1 cell lysate | +Inquiry |
NTRK1-2147HCL | Recombinant Human NTRK1 cell lysate | +Inquiry |
NTRK1-963CCL | Recombinant Canine NTRK1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1627 | TrkA Functional Assay Kit | +Inquiry |
Kit-1546 | U2OS TrkA Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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