NTRK1

  • Official Full Name

    neurotrophic tyrosine kinase, receptor, type 1

  • Overview

    This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
  • Synonyms

    NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Chicken
  • Dog
  • Homo sapiens (Human)
  • Human
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • hFc
  • His
  • DDK|His
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Avi
  • mFc
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NTRK1-166H Active Recombinant Human NTRK1, Fc Chimera Mammalian cells Fc Chimera
Human NTRK1-248H Active Recombinant Human NTRK1(440-end) Protein, N-His-tagged Sf21 His 440-end
Human NTRK1-448H Recombinant Human NTRK1, GST-tagged, Active Sf9 Insect Cell GST
Human NTRK1-297H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His Ala33-Gly423
Human NTRK1-155H Active Recombinant Human NTRK1 protein(Met1-Pro382), His&hFc-tagged HEK293 C-His&hFc Met1-Pro382
Human NTRK1-108H Recombinant Human NTRK1, Fc Chimera HEK293 Fc
Human NTRK1-973H Active Recombinant Human NTRK1, His tagged E.coli His Pro 285-Glu 413
Human NTRK1-31618TH Recombinant Human NTRK1 N/A
Human NTRK1-495H Recombinant Human NTRK1, Fc-tagged Mammalian cells Fc
Human NTRK1-717H Recombinant Human NTRK1, GST-His Sf9 Insect Cell GST
Human NTRK1-86H Recombinant Human NTRK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human NTRK1-977H Active Recombinant Human NTRK1 protein, His-tagged HEK293 His Pro194-Glu413
Human NTRK1-31619TH Recombinant Human NTRK1, Fc-tagged Fc
Human NTRK1-156H Recombinant Human NTRK1, His tagged HEK293 His Met 1-Pro 382
Human NTRK1-296H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His Ala33-Gly417
Human NTRK1-2147HCL Recombinant Human NTRK1 cell lysate Human Cell N/A
Human NTRK1-973HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated E.coli His 136
Human NTRK1-2030H Recombinant Human NTRK1 Protein, Fc/His-tagged HEK293 Fc/His Ala33-Glu407
Human NTRK1-973HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated E.coli His 136
Human NTRK1-1225H Recombinant Human NTRK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NTRK1-977HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 239
Human NTRK1-3080H Recombinant Human NTRK1 protein, His-tagged E.coli His 80-277 aa
Human NTRK1-155HAF488 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 598
Human NTRK1-156HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 361
Human NTRK1-973HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated E.coli His 136
Human NTRK1-977HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 239
Human NTRK1-155HF Recombinant Human NTRK1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 598
Human NTRK1-260H Recombinant Active Human NTRK1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Ala33-Glu407
Human NTRK1-977HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His 239
Human NTRK1-155HAF555 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 598
Human NTRK1-496H Recombinant Human NTRK1 protein, mFc-tagged HEK293 mFc Gly 192 - Val 402
Human NTRK1-130H Recombinant Human NTRK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NTRK1-2514H Recombinant Human NTRK1 Protein, His-tagged E.coli N-His Val278-Asn386
Human NTRK1-156HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 361
Human NTRK1-973HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated E.coli His 136
Human NTRK1-155HAF647 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 598
Human NTRK1-977HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 239
Human NTRK1-156HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 361
Human NTRK1-163N Active Recombinant Human NTRK1 Protein HEK293
Human NTRK1-156HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His 361
Human NTRK1-497H Recombinant Human NTRK1 protein, mFc-tagged HEK293 mFc Ala 33 - Gly 417
Human NTRK1-1505HFL Recombinant Full Length Human NTRK1 Protein, C-Flag-tagged Mammalian cells Flag
Human NTRK1-130H-B Recombinant Human NTRK1 Protein Pre-coupled Magnetic Beads HEK293
Human NTRK1-01H Active Recombinant Human NTRK1 Protein (34-407), Animal free HEK293 34-407
Mouse NTRK1-476M Recombinant Mouse Ntrk1, Fc tagged Human Cell His
Mouse NTRK1-415M Active Recombinant Mouse NTRK1 protein(Met1-Gly420), His-tagged HEK293 C-His Met1-Gly420
Mouse NTRK1-1086MCL Recombinant Mouse NTRK1 cell lysate Human Cell N/A
Mouse NTRK1-1971M Active Recombinant Mouse NTRK1 protein, hFc-tagged HEK293 hFc Met1-Gly420
Mouse NTRK1-476MF Recombinant Mouse Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 628
Mouse NTRK1-415MF Recombinant Mouse Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His 398
Mouse NTRK1-415MAF488 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 398
Mouse NTRK1-476MAF555 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 628
Mouse NTRK1-476MAF488 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 628
Mouse NTRK1-415MAF647 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 398
Mouse Ntrk1-4522M Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NTRK1-476MAF647 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 628
Mouse NTRK1-415MAF555 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 398
Rat NTRK1-03R Active Recombinant Rat NTRK1 protein, His-tagged HEK293 His 35-418aa
Rat NTRK1-1352R Acitve Recombinant Rat NTRK1 protein(Met1-Pro418), hFc-tagged HEK293 C-hFc Met1-Pro418
Rat Ntrk1-44R Recombinant Rat Ntrk1, Fc tagged Human Cell His
Rat NTRK1-4102R Recombinant Rat NTRK1 Protein Mammalian Cell His
Rat Ntrk1-45R Active Recombinant Rat Ntrk1 protein(Met1-Pro418), His-tagged HEK293 C-His Met1-Pro418
Rat Ntrk1-589R Recombinant Rat TrkA, FC Chimera Mammalian cells Fc
Rat NTRK1-1068RCL Recombinant Rat NTRK1 cell lysate Human Cell N/A
Rat Ntrk1-45RAF555 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 397
Rat Ntrk1-45RAF488 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 397
Rat Ntrk1-44RAF488 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 627
Rat Ntrk1-16R-B Recombinant Rat Ntrk1 Protein Pre-coupled Magnetic Beads HEK293
Rat Ntrk1-44RAF647 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 627
Rat Ntrk1-45RAF647 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 397
Rat Ntrk1-44RF Recombinant Rat Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 627
Rat Ntrk1-45RF Recombinant Rat Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His 397
Rat Ntrk1-16R Recombinant Rat Ntrk1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ntrk1-44RAF555 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 627
Rabbit NTRK1-509RAF555 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Ala33-Glu414, 393
Rabbit NTRK1-509RF Recombinant Rabbit NTRK1 Protein, His-tagged, FITC conjugated HEK293 His Ala33-Glu414, 393
Rabbit NTRK1-509R Active Recombinant Rabbit NTRK1 protein, His-tagged HEK293 His Ala33-Glu414
Rabbit NTRK1-509RAF488 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Ala33-Glu414, 393
Rabbit NTRK1-509RAF647 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Ala33-Glu414, 393
Dog NTRK1-295CF Recombinant Canine NTRK1 Protein, His-tagged, FITC conjugated HEK293 His 146
Dog NTRK1-295CAF488 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 146
Dog NTRK1-296CF Recombinant Canine NTRK1 Protein, Fc-tagged, FITC conjugated HEK293 Fc 386
Dog NTRK1-296CAF488 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 386
Dog NTRK1-295CAF647 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 146
Dog NTRK1-296CAF647 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 386
Dog NTRK1-295CAF555 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 146
Dog NTRK1-296CAF555 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 386
Canine NTRK1-1322C Acitve Recombinant Canine NTRK1 protein(Pro285-Lys410), hFc-tagged HEK293 N-hFc Pro285-Lys410
Canine NTRK1-296C Recombinant Canine NTRK1, Fc tagged Human Cell Fc/His
Canine NTRK1-295C Active Recombinant Canine NTRK1, His tagged HEK293 His Pro285-Lys410
Canine NTRK1-963CCL Recombinant Canine NTRK1 cell lysate Human Cell N/A
Homo sapiens (Human) RFL27953HF Recombinant Full Length Human High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-796)
Rattus norvegicus (Rat) RFL29589RF Recombinant Full Length Rat High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-799)
Zebrafish NTRK1-8470Z Recombinant Zebrafish NTRK1 Mammalian Cell His
Chicken NTRK1-6930C Recombinant Chicken NTRK1 Mammalian Cell His
Kit-1546 U2OS TrkA Bioassay Kit N/A
Kit-1627 TrkA Functional Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway, Endocytosis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAP2K2B;FGF1A;NFATC1;SRFA;RAC1A;ARRB2B;RAC1;PPM1B;MAP2K1
EndocytosisTFRC;H2-Q10;ARPC5A;FOLR2;SNX1;PSD;ARPC1A;ERBB3;RAB11FIP5
ApoptosisDFFB;BNIP3L;FADD;PRKAR1A;PIK3CA;DSG2;RELA;TRP53;RIPK1
Neurotrophin signaling pathwayMAPK11;BDNF;MAP3K1;MAPK13;NGFRAP1;SH2B3;GRB2;NFKBIE;CAMK2B
Inflammatory mediator regulation of TRP channelsHTR2B;TRPV4;TRPM8;HTR2A;ASIC3;PPP1CB;KLK1B4;CYP2C39;CYP2C50
Pathways in cancerLAMA2;TRAF3;GNB4;RAF1;NKX3-1;AGTR1B;HDAC1;TPM3;BMP4
Transcriptional misregulation in cancerFUS;MEF2C;NGFR;HIST1H3I;NR4A3;ZEB1;ERG;MYCN;CEBPE
Thyroid cancerNCOA4;PPARG;MAPK3;TRP53;RET;LEF1;NRAS;MAPK1;TPR
Central carbon metabolism in cancerHRAS;PIK3R5;RAF1;PIK3CD;SLC7A5;NRAS;PIK3CA;FLT3;SIRT6

NTRK1 has several biochemical functions, for example, ATP binding, ephrin receptor binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingBLK;RIOK2;BBS10;ATP12A;CASK;HSPE1;TSSK1;DDX6;ABCG2
ephrin receptor bindingEFNA1;SRC;EFNA1A;EFNB3B;EFNB1;SDCBP;CBL;FYN;NTRK3
kinase bindingTNFAIP3;PARK2;PRKAA1;PARK7;CHIA;CEBPA;STX1A;STRADA;CHP
nerve growth factor bindingPCSK6;NGFRB;NTRK1;SORT1;NGFR;FURIN
NOT nerve growth factor binding
nerve growth factor receptor activityNTRK1;SORT1
neurotrophin bindingNGFR;NTRK2;NTRK1;NTRK3
neurotrophin p75 receptor bindingZFP110;NRADD;NTRK1;NTF3
protein bindingSUV420H2;GDNF;KAT5;CAST;COPS5;RABAC1;KDRL;PBRM1;HBA2
protein homodimerization activityCD247;NPR3;LMLN;SERPINF2;CAV2;GPD1L;STC2;EFR3A;SNF8
transmembrane receptor protein tyrosine kinase activityNTRK3A;CSF1RA;ERBB4A;DDR1;ALK;INSRR;INSRB;EPHB2B;EPHA2

NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1.

NGF; NGF; Pirb; PLCG1; PIK3R1; SHC1; SORT1; PTPRC; PTPN1

Research Area

Related articles

Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).
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