NTRK1

  • Official Full Name

    neurotrophic tyrosine kinase, receptor, type 1

  • Overview

    This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
  • Synonyms

    NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canine
  • Chicken
  • Dog
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • hFc
  • His
  • DDK|His
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Avi
  • mFc
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NTRK1-166H Active Recombinant Human NTRK1, Fc Chimera Mammalian cells Fc Chimera
Human NTRK1-297H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His
Human NTRK1-448H Recombinant Human NTRK1, GST-tagged, Active Sf9 Insect Cell GST
Human NTRK1-108H Recombinant Human NTRK1, Fc Chimera HEK293 Fc
Human NTRK1-155H Active Recombinant Human NTRK1 protein(Met1-Pro382), His&hFc-tagged HEK293 C-His&hFc
Human NTRK1-31618TH Recombinant Human NTRK1 N/A
Human NTRK1-973H Active Recombinant Human NTRK1, His tagged E.coli His
Human NTRK1-717H Recombinant Human NTRK1, GST-His Sf9 Insect Cell GST
Human NTRK1-495H Recombinant Human NTRK1, Fc-tagged Mammalian cells Fc
Human NTRK1-977H Active Recombinant Human NTRK1 protein, His-tagged HEK293 His
Human NTRK1-86H Recombinant Human NTRK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human NTRK1-156H Recombinant Human NTRK1, His tagged HEK293 His
Human NTRK1-31619TH Recombinant Human NTRK1, Fc-tagged Fc
Human NTRK1-296H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His
Human NTRK1-2147HCL Recombinant Human NTRK1 cell lysate Human Cell N/A
Human NTRK1-973HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated E.coli His
Human NTRK1-2030H Recombinant Human NTRK1 Protein, Fc/His-tagged HEK293 Fc/His
Human NTRK1-973HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated E.coli His
Human NTRK1-1225H Recombinant Human NTRK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NTRK1-977HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human NTRK1-3080H Recombinant Human NTRK1 protein, His-tagged E.coli His
Human NTRK1-155HAF488 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Human NTRK1-156HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human NTRK1-973HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated E.coli His
Human NTRK1-977HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human NTRK1-155HF Recombinant Human NTRK1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Human NTRK1-260H Recombinant Active Human NTRK1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human NTRK1-977HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
Human NTRK1-155HAF555 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Human NTRK1-496H Recombinant Human NTRK1 protein, mFc-tagged HEK293 mFc
Human NTRK1-130H Recombinant Human NTRK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NTRK1-2514H Recombinant Human NTRK1 Protein, His-tagged E.coli N-His
Human NTRK1-156HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human NTRK1-973HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated E.coli His
Human NTRK1-155HAF647 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Human NTRK1-977HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human NTRK1-156HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human NTRK1-163N Active Recombinant Human NTRK1 Protein HEK293
Human NTRK1-156HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
Human NTRK1-497H Recombinant Human NTRK1 protein, mFc-tagged HEK293 mFc
Human NTRK1-1505HFL Recombinant Full Length Human NTRK1 Protein, C-Flag-tagged Mammalian cells Flag
Human NTRK1-130H-B Recombinant Human NTRK1 Protein Pre-coupled Magnetic Beads HEK293
Human NTRK1-01H Active Recombinant Human NTRK1 Protein (34-407), Animal free HEK293
Mouse NTRK1-476M Recombinant Mouse Ntrk1, Fc tagged Human Cell His
Mouse NTRK1-415M Active Recombinant Mouse NTRK1 protein(Met1-Gly420), His-tagged HEK293 C-His
Mouse NTRK1-1086MCL Recombinant Mouse NTRK1 cell lysate Human Cell N/A
Mouse NTRK1-1971M Active Recombinant Mouse NTRK1 protein, hFc-tagged HEK293 hFc
Mouse NTRK1-476MF Recombinant Mouse Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Mouse NTRK1-415MF Recombinant Mouse Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His
Mouse NTRK1-415MAF488 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Mouse NTRK1-476MAF555 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Mouse NTRK1-476MAF488 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Mouse NTRK1-415MAF647 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Mouse Ntrk1-4522M Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NTRK1-476MAF647 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Mouse NTRK1-415MAF555 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat NTRK1-03R Active Recombinant Rat NTRK1 protein, His-tagged HEK293 His
Rat NTRK1-1352R Acitve Recombinant Rat NTRK1 protein(Met1-Pro418), hFc-tagged HEK293 C-hFc
Rat Ntrk1-44R Recombinant Rat Ntrk1, Fc tagged Human Cell His
Rat NTRK1-4102R Recombinant Rat NTRK1 Protein Mammalian Cell His
Rat Ntrk1-45R Active Recombinant Rat Ntrk1 protein(Met1-Pro418), His-tagged HEK293 C-His
Rat Ntrk1-589R Recombinant Rat TrkA, FC Chimera Mammalian cells Fc
Rat NTRK1-1068RCL Recombinant Rat NTRK1 cell lysate Human Cell N/A
Rat Ntrk1-45RAF555 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat Ntrk1-45RAF488 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rat Ntrk1-44RAF488 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat Ntrk1-16R-B Recombinant Rat Ntrk1 Protein Pre-coupled Magnetic Beads HEK293
Rat Ntrk1-44RAF647 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat Ntrk1-45RAF647 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Rat Ntrk1-44RF Recombinant Rat Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat Ntrk1-45RF Recombinant Rat Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His
Rat Ntrk1-16R Recombinant Rat Ntrk1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ntrk1-44RAF555 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rabbit NTRK1-509RAF555 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rabbit NTRK1-509RF Recombinant Rabbit NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
Rabbit NTRK1-509R Active Recombinant Rabbit NTRK1 protein, His-tagged HEK293 His
Rabbit NTRK1-509RAF488 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rabbit NTRK1-509RAF647 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Dog NTRK1-295CF Recombinant Canine NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
Dog NTRK1-295CAF488 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Dog NTRK1-296CF Recombinant Canine NTRK1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Dog NTRK1-296CAF488 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Dog NTRK1-295CAF647 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Dog NTRK1-296CAF647 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Dog NTRK1-295CAF555 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Dog NTRK1-296CAF555 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Canine NTRK1-1322C Acitve Recombinant Canine NTRK1 protein(Pro285-Lys410), hFc-tagged HEK293 N-hFc
Canine NTRK1-296C Recombinant Canine NTRK1, Fc tagged Human Cell Fc/His
Canine NTRK1-295C Active Recombinant Canine NTRK1, His tagged HEK293 His
Canine NTRK1-963CCL Recombinant Canine NTRK1 cell lysate Human Cell N/A
Homo sapiens (Human) RFL27953HF Recombinant Full Length Human High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL29589RF Recombinant Full Length Rat High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His
Zebrafish NTRK1-8470Z Recombinant Zebrafish NTRK1 Mammalian Cell His
Chicken NTRK1-6930C Recombinant Chicken NTRK1 Mammalian Cell His
Kit-1546 U2OS TrkA Bioassay Kit N/A
Kit-1627 TrkA Functional Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NTRK1 Related Articles

NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway, Endocytosis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayZAK;MAPK10;HSPB1;CACNG6A;Pdgfa&Pdgfb;FGF1B;PPM1AB;NFATC3;PRKCG
EndocytosisHRAS;ASAP1;ADRB2A;ARRB2;PLD1;ASAP3;SH3GLB2;RAB11B;SH3GL2
ApoptosisIRF1B;CAPN2B;NFKBIAB;PPP3R1B;CAPN1;DFFB;BCL2L1;APAF1;AKT3A
Neurotrophin signaling pathwayPIK3CB;MAPK8;RPS6KA3;PIK3R3;ARHGDIB;SHC1;ZFP110;NGFRAP1;RAF1
Inflammatory mediator regulation of TRP channelsPLA2G6;CALM3;IL1B;PRKACA;PPP1CA;PLA2G4F;PRKCD;PRKCG;CALML5
Pathways in cancerBCL2;AKT1;CASP9;Shh;Casp3;GNAI2;Fzd4;ITGA6;RELA
Transcriptional misregulation in cancerETV1;FUS;Pdgfa&Pdgfb;PAX8;HIST2H3C2;BCL6;DOT1L;PBX3;NFKB1
Thyroid cancerMAPK1;RXRB;RXRG;PPARG;CDH1;RET;MAP2K1;RXRA;TCF7L2
Central carbon metabolism in cancerPGAM2;NRAS;HK2;PDHA1;G6PD;ERBB2;PFKL;PFKM;PDHB

NTRK1 has several biochemical functions, for example, ATP binding, ephrin receptor binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingUBE2D1;NLRP11;ABCB4;TAP2;TTL;UBE2IA;DYRK1B;MTHFD1L;DDX6
ephrin receptor bindingEFNA2;EFNA5;EPHA4;PTPN1;SIPA1L1;EFNA2A;CDK5R1;CDK5;SHC1
kinase bindingDGKQ;PARK2;SNAI1;PTPN22;GFAP;SIT1;C2orf44;BARD1;NTRK1
nerve growth factor bindingNGFRB;NTRK1;FURIN;SORT1;PCSK6;NGFR
NOT nerve growth factor binding
nerve growth factor receptor activityNTRK1;SORT1
neurotrophin bindingNTRK3;NGFR;NTRK1;NTRK2
neurotrophin p75 receptor bindingNRADD;NTF3;ZFP110;NTRK1
protein bindingHOXB5;GSS;CNKSR3;CCDC101;Unc5b;NR4A1;MTMR4;CDC14B;MEX3C
protein homodimerization activityPEX7;KCNN2;BAXB;IDH1;AGR2;PARK7;TERF1;TIRAP;NUDT16
transmembrane receptor protein tyrosine kinase activityFLT1;AXL;DDR2;MUSK;INSRR;EPHA4B;TYRO3;EPHB4B;EPHA2

NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1.

NGF; NGF; Pirb; PLCG1; PIK3R1; SHC1; SORT1; PTPRC; PTPN1

Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).
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