NTRK1 Protein

NTRK1

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NTRK1

Official Full Name neurotrophic tyrosine kinase, receptor, type 1
Background This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Synonyms NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
    • Species :
    • Canine
    • Chicken
    • Dog
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rattus norvegicus (Rat)
    • Zebrafish
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • His
    • Fc
    • Fc Chimera
    • Fc/His
    • Fc-His(C-ter)
    • Flag
    • GST
    • Myc/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NTRK1-166H Recombinant Human NTRK1, Fc Chimera Mammalian cells Fc Chimera
    Rat NTRK1-03R Recombinant Rat NTRK1 protein, His-tagged HEK293 His
    Human NTRK1-108H Recombinant Human NTRK1, Fc Chimera HEK293 Fc
    Human NTRK1-155H Recombinant Human NTRK1, Fc-His tagged Human Cell Fc/His
    Human NTRK1-156H Recombinant Human NTRK1, His tagged Human Cell His
    Human NTRK1-296H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His
    Human NTRK1-297H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 DDK/His
    Human NTRK1-31618TH Recombinant Human NTRK1 N/A
    Human NTRK1-31619TH Recombinant Human NTRK1, Fc-tagged Fc
    Human NTRK1-448H Recombinant Human NTRK1, GST-tagged, Active Sf9 Insect Cell GST
    Human NTRK1-495H Recombinant Human NTRK1, Fc-tagged Mammalian cells Fc
    Human NTRK1-717H Recombinant Human NTRK1, GST-His Sf9 Insect Cell GST
    Human NTRK1-86H Recombinant Human NTRK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human NTRK1-973H Recombinant Human NTRK1, His tagged E.coli His
    Human NTRK1-977H Recombinant Human NTRK1, His tagged Human Cell His
    Mouse NTRK1-415M Recombinant Mouse Ntrk1, His tagged Human Cell His
    Mouse NTRK1-476M Recombinant Mouse Ntrk1, Fc tagged Human Cell His
    Rat NTRK1-4102R Recombinant Rat NTRK1 Protein Mammalian Cell His
    Rat Ntrk1-44R Recombinant Rat Ntrk1, Fc tagged Human Cell His
    Rat Ntrk1-45R Recombinant Rat Ntrk1, His tagged Human Cell His
    Rat Ntrk1-589R Recombinant Rat TrkA, FC Chimera Mammalian cells Fc
    Canine NTRK1-295C Recombinant Canine NTRK1, His tagged Human Cell His
    Canine NTRK1-296C Recombinant Canine NTRK1, Fc tagged Human Cell Fc/His
    Chicken NTRK1-6930C Recombinant Chicken NTRK1 Mammalian Cell His
    Zebrafish NTRK1-8470Z Recombinant Zebrafish NTRK1 Mammalian Cell His
    Human NTRK1-2147HCL Recombinant Human NTRK1 cell lysate Human Cell N/A
    Mouse NTRK1-1086MCL Recombinant Mouse NTRK1 cell lysate Human Cell N/A
    Rat NTRK1-1068RCL Recombinant Rat NTRK1 cell lysate Human Cell N/A
    Canine NTRK1-963CCL Recombinant Canine NTRK1 cell lysate Human Cell N/A
    Human NTRK1-155HAF488 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Human NTRK1-155HAF555 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Human NTRK1-155HAF647 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Human NTRK1-155HF Recombinant Human NTRK1 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human NTRK1-156HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human NTRK1-156HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human NTRK1-156HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human NTRK1-156HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
    Human NTRK1-2514H Recombinant Human NTRK1 Protein, His-tagged E.coli N-His
    Human NTRK1-260H Recombinant Active Human NTRK1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
    Dog NTRK1-295CAF488 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Dog NTRK1-295CAF555 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Dog NTRK1-295CAF647 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Dog NTRK1-295CF Recombinant Canine NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
    Dog NTRK1-296CAF488 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Dog NTRK1-296CAF555 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Dog NTRK1-296CAF647 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Dog NTRK1-296CF Recombinant Canine NTRK1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human NTRK1-3080H Recombinant Human NTRK1 protein, His-tagged E.coli His
    Mouse NTRK1-415MAF488 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Mouse NTRK1-415MAF555 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Mouse NTRK1-415MAF647 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Mouse NTRK1-415MF Recombinant Mouse Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His
    Rat Ntrk1-44RAF488 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Rat Ntrk1-44RAF555 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Rat Ntrk1-44RAF647 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Rat Ntrk1-44RF Recombinant Rat Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Rat Ntrk1-45RAF488 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rat Ntrk1-45RAF555 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rat Ntrk1-45RAF647 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rat Ntrk1-45RF Recombinant Rat Ntrk1 Protein, His-tagged, FITC conjugated HEK293 His
    Mouse NTRK1-476MAF488 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Mouse NTRK1-476MAF555 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Mouse NTRK1-476MAF647 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Mouse NTRK1-476MF Recombinant Mouse Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Rabbit NTRK1-509RAF488 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rabbit NTRK1-509RAF555 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rabbit NTRK1-509RAF647 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rabbit NTRK1-509RF Recombinant Rabbit NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
    Human NTRK1-973HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated E.coli His
    Human NTRK1-973HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated E.coli His
    Human NTRK1-973HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated E.coli His
    Human NTRK1-973HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated E.coli His
    Human NTRK1-977HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human NTRK1-977HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human NTRK1-977HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human NTRK1-977HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 His
    Homo sapiens (Human) RFL27953HF Recombinant Full Length Human High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His
    Rattus norvegicus (Rat) RFL29589RF Recombinant Full Length Rat High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system His
    Human NTRK1-1225H Recombinant Human NTRK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human NTRK1-2030H Recombinant Human NTRK1 Protein, Fc/His-tagged HEK293 Fc/His
    Mouse Ntrk1-4522M Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rabbit NTRK1-509R Recombinant Rabbit NTRK1 Protein, His-tagged HEK293 His
    Kit-1546 U2OS TrkA Bioassay Kit N/A
    Kit-1627 TrkA Functional Assay Kit N/A

    NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway, Endocytosis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RPS6KA3A; FGF6B; PDGFRB; MAP3K7; FGF13A; FOS; MAP3K13; MEF2CB; MAP4K3; FGF6
    Endocytosis TRAF6; CYTH1A; RAB31; IGF2R; RAB11FIP3; SMURF1; BIN1; BIN1B; CDC42L2; SNX4
    Apoptosis CASP6L2; MYC; CTNNB1; TRAF2; PPP3CC; DFFB; BAX; PIK3R1; BCL2A; MAP3K14
    Neurotrophin signaling pathway BAD; NGFRAP1; ARHGDIG; NTRK1; PDPK1; SHC2; RPS6KA6; RAC1; PIK3CD; SORT1
    Inflammatory mediator regulation of TRP channels PLA2G4F; CYP2J6; IL1B; HTR2C; CAMK2B; PIK3R1; ASIC1; ASIC2; NGF; ACCN5
    Pathways in cancer VHL; FGF21; Kitl; HSP90AB1; RELA; SOS1; FGF22; FGF14; RXRA; FADD
    Transcriptional misregulation in cancer FLI1; GOLPH3; MLLT3; Itgam&Itgb2; SFPI1; NR4A3; RARA; ETV4; ZBTB17; BCL2L1
    Thyroid cancer TCF7; RXRG; NTRK1; CCND1; MAPK1; TRP53; NCOA4; PAX8; RXRB; TCF7L2
    Central carbon metabolism in cancer MTOR; FLT3; PIK3CB; SIRT3; LDHA; HK3; FGFR1; PIK3CD; HK1; PIK3R5

    NTRK1 has several biochemical functions, for example, ATP binding, ephrin receptor binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MYH10; PRKAA2; TEP1; THRAP3; CSK; EIF4A2; PHKG2; KIF17; CNTN1B; ATP8B3
    ephrin receptor binding SHC1; NTRK1; NTRK3; CDK5R1; EFNA5B; CDK5; Anks1; EFNA2; EPHA7; FYN
    kinase binding FAS; TOLLIP; PARK2; CHIA; BTG1; SP100; ATF5; BARD1; CHP1; TRADD
    nerve growth factor binding FURIN; SORT1; NTRK1; NGFR; NGFRB; PCSK6
    NOT nerve growth factor binding NTRK1
    nerve growth factor receptor activity SORT1; NTRK1
    neurotrophin binding NTRK3; NGFR; NTRK1; NTRK2
    neurotrophin p75 receptor binding NTF3; NRADD; ZFP110; NTRK1
    protein binding UHRF1; PRDM13; E2F3; INMT; GJB6; SIN3B; DPH3; DPP4; TLR13; MAP1LC3C
    protein homodimerization activity ABAT; HRSP12; TARS; FLT3; GABRR1; PAFAH1B2; TIMM9; GNB2L1; ANG; UGT1A9
    transmembrane receptor protein tyrosine kinase activity TIE1; NPTN; CADM2B; NTRK3; AXL; RYK; ERBB4; TEK; EK1; FLT4

    NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1.

    NGF; NGF; Pirb; PLCG1; PIK3R1; SHC1; SORT1; PTPRC; PTPN1

    Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
    Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).

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