Recombinant Human ODF2

• Cat.No.: ODF2-27389TH
• Product Overview: Recombinant fragment of Human Cenexin1/ODF2 Isoform 3 with a N terminal proprietary tag: predicted molecular weight 36.52 kDa inclusive of tag.

Specification

• Description: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as Cenexins, encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Testis-specific (at protein level). Highly expressed in cytoplasm of step 2 round spermatids. Detected in the middle piece and extends to about half the principal piece of the sperm tails.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: KEHALSKERAAQNKILDLETQLSRT KTELSQLRRSRDDADRRYQSRLQDL KDRLEQSESTNRSMQNYVQFLKSSY ANVFGDGPYSTFLTSSPIRSRSPP*
• Sequence Similarities: Belongs to the ODF2 family.

Gene Information

• Gene Name: ODF2 outer dense fiber of sperm tails 2 [ Homo sapiens ]
• Official Symbol: ODF2
• Synonyms: ODF2; outer dense fiber of sperm tails 2; outer dense fibre of sperm tails 2; outer dense fiber protein 2; cancer/testis antigen 134; CT134; ODF84
• Gene ID: 4957
• mRNA Refseq: NM_001242352
• Protein Refseq: NP_001229281
• MIM: 602015
• Uniprot ID: Q5BJF6
• Chromosome Location: 9q34
• Pathway: Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem
• Function: protein binding; structural molecule activity