"PARP3" Related Products


Recombinant Human PARP3, GST-tagged

Cat.No.: PARP3-27634TH
Product Overview: Recombinant full length Human PARP3 with N terminal GST-tag expressed in a Baculovirus infected Sf9 cell expression system, 87 kDa.
Description: The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Conjugation: GST
Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Biological activity: Specific Activity: 207.5 U/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain.
Gene Name: PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ]
Official Symbol: PARP3
Synonyms: PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase
Gene ID: 10039
mRNA Refseq: NM_001003931
Protein Refseq: NP_001003931
MIM: 607726
Uniprot ID: Q9Y6F1
Chromosome Location: 3p22.2-p21.1
Pathway: BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem;
Function: NAD+ ADP-ribosyltransferase activity; catalytic activity; transferase activity, transferring glycosyl groups;

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