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Recombinant Human PEBP1

Cat. No.: PEBP1-29533TH
Product Overview: Recombinant human PEBP1 was expressed in E. coli and purified by using conventional chromatography techniques.
Description: Phosphatidylethanolamine binding protein 1 (PEBP1) is a member of the phosphatidylethanolamine-binding protein family and a serine protease inhibitor which inhibits thrombin, neuropsin. PEBP1 plays a pivotal modulatory role in several protein kinase signaling cascades. Protein kinase C (PKC) phosphorylates PEBP1, resulting in release of Raf-1 and activation of MEK and ERK. Expressed in many tissues, PEBP1 is implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.
Source: E. coli
Molecular Mass: 21 kDa (187aa), confirmed by MALDI-TOF.
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
Purity: > 95% by SDS - PAGE
Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method )
Applications: SDS-PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4oC short term (1-2 weeks). For long term storage, aliquot and store at -20oC or -70oC. Avoid repeated freezing and thawing cycles.
OfficialSymbol: PEBP1
Gene Name: PEBP1 phosphatidylethanolamine binding protein 1 [ Homo sapiens ]
Synonyms: PEBP1; phosphatidylethanolamine binding protein 1; PBP, prostatic binding protein; phosphatidylethanolamine-binding protein 1; HCNP; hippocampal cholinergic neurostimulating peptide; PEBP; Raf kinase inhibitory protein; RKIP
Gene ID: 5037
mRNA Refseq: NM_002567
Protein Refseq: NP_002558
MIM: 604591
UniProt ID: P30086
Chromosome Location: 12q24.23
Pathway: Aurora B signaling; EGFR1 Signaling Pathway; ErbB1 downstream signaling; TNF-alpha/NF-kB Signaling Pathway
Function: ATP binding; mitogen-activated protein kinase binding; phosphatidylethanolamine binding; receptor binding; serine-type endopeptidase inhibitor activity

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