Recombinant Human PSMC3
Cat.No. : | PSMC3-31224TH |
Product Overview : | Recombinant fragment of Human PSMC3 with an N terminal proprietary tag; Predicted MWt 36.63 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MNLLPNIESPVTRQEKMATVWDEAE QDGIGEEVLKMSTEEIIQRTRLLDS EIKIMKSEVLRVTHELQAMKDKIKE NSEKIKVNKTLPYLVSNVIELLDVD |
Sequence Similarities : | Belongs to the AAA ATPase family. |
Gene Name : | PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 [ Homo sapiens ] |
Official Symbol : | PSMC3 |
Synonyms : | PSMC3; proteasome (prosome, macropain) 26S subunit, ATPase, 3; 26S protease regulatory subunit 6A; TBP 1; TBP1; |
Gene ID : | 5702 |
mRNA Refseq : | NM_002804 |
Protein Refseq : | NP_002795 |
MIM : | 186852 |
Uniprot ID : | P17980 |
Chromosome Location : | 11p11.2 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; |
Function : | ATP binding; hydrolase activity; nucleoside-triphosphatase activity; nucleotide binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Psmc3-5184M | Recombinant Mouse Psmc3 Protein, Myc/DDK-tagged | +Inquiry |
PSMC3-420H | Recombinant Human PSMC3 Protein, His-tagged | +Inquiry |
PSMC3-4439R | Recombinant Rat PSMC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
PSMC3-7217M | Recombinant Mouse PSMC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
PSMC3-3482R | Recombinant Rhesus Macaque PSMC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PSMC3-2763HCL | Recombinant Human PSMC3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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