Recombinant Human PTPN7

• Cat.No.: PTPN7-26537TH
• Product Overview: Recombinant full length HePTP / PTPN7 protein (Human), was expressed in E coli using an N-terminal tag, MW 67 kDa.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.
• Source: E. coli
• Tissue specificity: Expressed exclusively in thymus and spleen.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 50mM Sodium chloride, 20mM MOPS, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 tyrosine-protein phosphatase domain.

Gene Information

• Gene Name: PTPN7 protein tyrosine phosphatase, non-receptor type 7 [ Homo sapiens ]
• Official Symbol: PTPN7
• Synonyms: PTPN7; protein tyrosine phosphatase, non-receptor type 7; tyrosine-protein phosphatase non-receptor type 7; HEPTP; LC PTP
• Gene ID: 5778
• mRNA Refseq: NM_001199797
• Protein Refseq: NP_001186726
• MIM: 176889
• Uniprot ID: P35236
• Chromosome Location: 1q32.1
• Pathway: Downstream signaling in naive CD8+ T cells, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Ras signaling in the CD4+ TCR pathway, organism-specific biosystem
• Function: hydrolase activity; protein tyrosine phosphatase activity