Recombinant Human PTPN7 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PTPN7-4695H
• Product Overview: PTPN7 MS Standard C13 and N15-labeled recombinant protein (NP_542155) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.
• Molecular Mass: 45 kDa
• AA Sequence: MGASFWPIRQAREQQRRALSFRQTSWLSEPPLGPAPHLSMVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSPTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PTPN7 protein tyrosine phosphatase non-receptor type 7 [ Homo sapiens (human) ]
• Official Symbol: PTPN7
• Synonyms: PTPN7; protein tyrosine phosphatase, non-receptor type 7; tyrosine-protein phosphatase non-receptor type 7; HEPTP; LC PTP; dual specificity phosphatase 1; protein-tyrosine phosphatase LC-PTP; hematopoietic protein-tyrosine phosphatase; protein-tyrosine phosphatase, nonreceptor-type, stress induced; LPTP; PTPNI; BPTP-4; LC-PTP; FLJ18703
• Gene ID: 5778
• mRNA Refseq: NM_080588
• Protein Refseq: NP_542155
• MIM: 176889
• UniProt ID: P35236