||Recombinant full length glycolyslated Human PAI1 containing mutations which confer additional stability to the otherwise labile molecule, expressed in insect cells; MWt 46kDa.
||This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
||Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
||Kinetic Data:Second order rate constants for inhibition of:uPA = 6.3 X 106 M-1s-1tPA = 5.7 X 106 M-1s-195 (+/-) 5% active by uPA titration
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA, pH 6.6
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Belongs to the serpin family.