Recombinant Human SERPINE1

• Cat.No.: SERPINE1-28262TH
• Product Overview: Recombinant full length glycolyslated Human PAI1 containing mutations which confer additional stability to the otherwise labile molecule, expressed in insect cells; MWt 46kDa.

Specification

• Description: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Tissue specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
• Biological activity: Kinetic Data:Second order rate constants for inhibition of:uPA = 6.3 X 106 M-1s-1tPA = 5.7 X 106 M-1s-195 (+/-) 5% active by uPA titration
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA, pH 6.6
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the serpin family.

Gene Information

• Gene Name: SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Homo sapiens ]
• Official Symbol: SERPINE1
• Synonyms: SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1, PLANH1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inh
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• Uniprot ID: P05121
• Chromosome Location: 7q21.3-q22
• Pathway: Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem
• Function: peptidase inhibitor activity; protease binding; protein binding; contributes_to receptor binding; serine-type endopeptidase inhibitor activity