Recombinant Human STK11, His-tagged

• Cat.No.: STK11-29853TH
• Product Overview: Recombinant fragment, corresponding to amino acids 116-433 of Human LKB1 with an N terminal His tag. Predicted MWt: 36 kDa

Specification

• Description: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
• Form: Lyophilised:Reconstitute with 150 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: VLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHG YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKIS DLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSG FKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGS YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF RKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADE DEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLP KAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIR RLSACKQQ
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: STK11 serine/threonine kinase 11 [ Homo sapiens ]
• Official Symbol: STK11
• Synonyms: STK11; serine/threonine kinase 11; serine/threonine kinase 11 (Peutz Jeghers syndrome); serine/threonine-protein kinase STK11; LKB1; PJS; polarization related protein LKB1
• Gene ID: 6794
• mRNA Refseq: NM_000455
• Protein Refseq: NP_000446
• MIM: 602216
• Uniprot ID: Q15831
• Chromosome Location: 19p13.3
• Pathway: AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem
• Function: ATP binding; LRR domain binding; magnesium ion binding; nucleotide binding; p53 binding