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Recombinant Human VHL, His-tagged

Cat.No. : VHL-28605TH
Product Overview : Recombinant full length human Von Hippel Lindau protein with His tag expressed in a baculovirus system; 213 amino acids, 24kDa.
  • Specification
  • Gene Information
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Description : Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Conjugation : HIS
Tissue specificity : Expressed in the adult and fetal brain and kidney.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : VHL von Hippel-Lindau tumor suppressor [ Homo sapiens ]
Official Symbol : VHL
Synonyms : VHL; von Hippel-Lindau tumor suppressor; von Hippel Lindau syndrome; von Hippel-Lindau disease tumor suppressor; VHL1;
Gene ID : 7428
mRNA Refseq : NM_000551
Protein Refseq : NP_000542
MIM : 608537
Uniprot ID : P40337
Chromosome Location : 3p25.3
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;
Function : protein binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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