"VHL" Related Products


Recombinant Human VHL, His-tagged

Cat.No.: VHL-28605TH
Product Overview: Recombinant full length human Von Hippel Lindau protein with His tag expressed in a baculovirus system; 213 amino acids, 24kDa.
Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Conjugation: HIS
Tissue specificity: Expressed in the adult and fetal brain and kidney.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name: VHL von Hippel-Lindau tumor suppressor [ Homo sapiens ]
Official Symbol: VHL
Synonyms: VHL; von Hippel-Lindau tumor suppressor; von Hippel Lindau syndrome; von Hippel-Lindau disease tumor suppressor; VHL1;
Gene ID: 7428
mRNA Refseq: NM_000551
Protein Refseq: NP_000542
MIM: 608537
Uniprot ID: P40337
Chromosome Location: 3p25.3
Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem;
Function: protein binding; transcription factor binding;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.