"PAIP2" Related Products

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Recombinant Human PAIP2, His-tagged

Cat. No.: PAIP2-1816H
Product Overview: Recombinant human PAIP2 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 17.1 kDa (147aa).
Description: PAIP2, also known as Poly(A)-binding protein-interacting protein 2, acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. It displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI
Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol.
Purity: > 90% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PAIP2 poly(A) binding protein interacting protein 2 [ Homo sapiens ]
Synonyms: PAIP2; poly(A) binding protein interacting protein 2; PAIP2A; MGC72018; PABP-interacting protein 2; PABC1-interacting protein 2; polyA-binding protein-interacting protein 2; polyadenylate-binding protein-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2
Gene ID: 51247
mRNA Refseq: NM_001033112
Protein Refseq: NP_001028284
MIM: 605604
UniProt ID: Q9BPZ3
Chromosome Location: 5q31.2
Function: protein binding; translation repressor activity

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