"AMOT" Related Products

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Recombinant Human Angiomotin

Cat. No.: AMOT-1989H
Product Overview: Recombinant human AMOT (a.a. 259) is produced inE.coli,30.0 kDa.
Description: Ang K1-3 is a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. More active relative to kringles 1-4. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.
Source: E.coli.
Amino Acid Sequence: VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPAT HPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGE NYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKK NYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGP TYQCLKGTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 95.0% as determined by: Analysis by RP-HPLC; Analysis by SDS-PAGE.
Formulation: Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM NaAc, pH5.5, 4% mannitol.
Solubility: We recommend to briefly centrifuge the vial prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: The lyophilized Angiostatin K1-3 is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: AMOT angiomotin [ Homo sapiens ]
Synonyms: angiomotin; KIAA1071; AMOT; angiomotin p80 isoform; angiomotin p130 isoform
Gene ID: 154796
mRNA Refseq: NM_001113490
Protein Refseq: NP_001106962
MIM: 300410
UniProt ID: Q4VCS5
Chromosome Location: Xq23
Function: angiostatin binding; protein binding; receptor activity

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