Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human C-terminal Binding Protein 1

Cat.No. : CTBP1-2027H
Product Overview : Recombinant human CtBP1 was expressed inE.coliand purified by using conventional chromatography techniques. MW = 47.5 kDa (440aa).
  • Specification
  • Gene Information
  • Related Products
Cat. No. : CTBP1-2027H
Description : C-terminal-binding protein 1 isoform 1, also known as CtBP1, is expressed from embryo to adult. This protein binds to the C-terminus of adenovirus E1A. It is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. Also, CtBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression.
Source : E. coli.
Sequences Of Amino Acids : MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL.
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 100mM NaCl, 10% glycerol.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
Gene Name : CTBP1 C-terminal binding protein 1 [ Homo sapiens ]
Synonyms : CTBP1; C-terminal binding protein 1; BARS; MGC104684; brefeldin A-ribosylated substrate; C-terminal-binding protein 1; CtBP1; EC 1.1.1.-; CTBP
Gene ID : 1487
mRNA Refseq : NM_001012614
Protein Refseq : NP_001012632
MIM : 602618
UniProt ID : Q13363
Chromosome Location : 4p16
Pathway : Chronic myeloid leukemia; Notch signaling pathway; Pathways in cancer; Wnt signaling pathway
Function : NAD or NADH binding; cofactor binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein C-terminus binding; protein binding; protein domain specific binding; transcription factor activity; transcription factor binding; transcription repressor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary role of CTBP1 in gene regulation? 02/19/2023

CTBP1 is a transcriptional co-repressor, regulating gene expression.

How do genetic variations in CTBP1 affect cellular differentiation? 09/15/2022

Genetic changes in CTBP1 affect cell development and differentiation.

How does CTBP1 interact with other transcriptional regulators? 02/11/2022

CTBP1 collaborates with transcription factors, influencing gene regulation.

What role does CTBP1 play in developmental processes? 10/07/2020

CTBP1 is involved in developmental processes and cell differentiation.

What potential therapeutic applications arise from targeting CTBP1 in diseases? 11/02/2019

Targeting CTBP1 could treat diseases with abnormal gene expression, including cancer.

How does CTBP1 contribute to transcriptional repression? 11/24/2018

It plays a key role in transcriptional repression, impacting gene activity.

What is the impact of altered CTBP1 activity on cancer progression? 04/08/2018

Altered CTBP1 activity is associated with cancer progression.

Customer Reviews (3)

Write a review
Reviews
10/12/2022

    Key to our research success, an integral research partner.

    02/15/2018

      Efficient and precise, a trusted research collaborator.

      04/03/2017

        Dependable partner, crucial for research integrity.

        Ask a Question for All CTBP1 Products

        Required fields are marked with *

        My Review for All CTBP1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends