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Recombinant Human PLA2G7, His-tagged

Cat. No.: PLA2G7-581H.
Product Overview: Recombinant Human phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) is expressed inE. coliwith N-terminal His-tagged. The molecular weight of the recombinant human PLA2G7 is 46.4 kDa.
Description: Platelet-activating factor acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids. Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level. PAF deacetylation by PAF-AH causes loss of biological activity, making PAF-AH potential useful as an anti-inflammation therapy. Human recombinant PAF-AH was characterized using 2-Thio PAF as a substrate, which upon hydrolysis by PAF-AH releases a free thiol that reacts with 5,5-dithio-bis(2-dinitrobenzoic acid) (DTNB) to produce 5-thio-2-nitrobenzoic acid (TNB) with an absorbance maximum at 412 nm.
Source: E. coli.
Purity: Greater than 95% as determined by SDS-PAGE.
Formulation: 100 mM Sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.
Storage: -80℃. 1 year.
Gene Name: PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [ Homo sapiens ]
Synonyms: PLA2G7; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); LP-PLA2; Platelet-Activating Factor Acetylhydrolase; PAF-AH;Lipoprotein PLA2; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; PAFAH; lipoprotein-associated phospholipase A2; LDL-PLA2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase
Gene ID: 7941
mRNA Refseq: NM_001168357
Protein Refseq: NP_001161829
MIM: 601690
UniProt ID: Q13093
Chromosome Location: 6p21.2-p12
Pathway: Ether lipid metabolism; Metabolic pathways; Diabetes pathways
Function: 1-alkyl-2-acetylglycerophosphocholine esterase activity; hydrolase activity; phospholipid binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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