Recombinant Mouse Telomerase Reverse Transcriptase
Cat.No. : | Tert-574M |
Product Overview : | Recombinant Mouse telomerase reverse transcriptase is expressed inE. coli. TERT encoding 174-341 amino acids. The molecular weight of the recombinant Tert is 46 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Tert-574M. |
Description : | Telomeres are specialized structures at the ends of eukaryotic chromosomes which appear to function in chromosome stabilization, positioning and replication. At each cell division, the length of telomeric TTAGGG DNA repeats is shortened and cells ultimately stop dividing. Telomerase is a reverse transcriptase that synthesizes telomere DNA thereby compensating for telomere loss. Telomerease is expressed mainly in the nucleus of proliferating cells and lymphocytes. |
Source : | E. coli. |
Purity : | >90%. |
Physical Appearance : | Sterile filtered liquid. |
Formulation : | Telomerase protein at 100μg/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. |
Storage : | Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles. |
Gene Name : | Tert telomerase reverse transcriptase [ Mus musculus ] |
Synonyms : | telomerase reverse transcriptase; Tert; TR; TP2; TRT; EST2; TCS1; hEST2; MGC150124; telomerase catalytic subunit; telomerase-associated protein 2 |
Gene ID : | 21752 |
mRNA Refseq : | NM_009354 |
Protein Refseq : | NP_033380 |
UniProt ID : | O14746 |
Chromosome Location : | 13 C1 |
Function : | nucleotidyltransferase activity; DNA binding; RNA binding;protein binding; RNA-directed DNA polymerase activity; telomerase activity; telomeric template RNA reverse transcriptase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
TERT-5673R | Recombinant Rat TERT Protein, His (Fc)-Avi-tagged | +Inquiry |
TERT-9132M | Recombinant Mouse TERT Protein, His (Fc)-Avi-tagged | +Inquiry |
TERT-438H | Recombinant Human TERT Protein, His/GST-tagged | +Inquiry |
Tert-440R | Recombinant Rat Tert Protein, His-tagged | +Inquiry |
Tert-1383M | Recombinant Mouse Tert Protein, His-SUMO-tagged | +Inquiry |
◆ Lysates | ||
TERT-1144HCL | Recombinant Human TERT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, mutations in the TERT gene have been identified in certain genetic disorders. Understanding these mutations can be crucial for diagnosing and managing related conditions.
One challenge is the potential impact on normal, healthy cells, as they also rely on TERT for telomere maintenance. Specific targeting of cancer cells without affecting normal cells is a significant hurdle.
The ethical implications include concerns about unintended consequences, potential misuse, and ensuring equitable access to TERT-based therapies.
Research suggests that TERT expression levels may be indicative of treatment response. Patients with higher TERT expression might respond differently to certain therapies.
TERT's role in maintaining telomeres is linked to cellular aging. Exploring ways to modulate TERT expression could have implications for anti-aging interventions.
Customer Reviews (3)
Write a reviewThis existing knowledge base provides a solid foundation for designing experiments and interpreting results, ultimately enhancing the efficiency and reliability of trials involving TERT protein.
With their support, I can confidently explore the intricacies of TERT and make significant contributions to the understanding of its functions in various biological processes.
Extensive research has been conducted on TERT, making it relatively accessible and well-understood in terms of its structure and functions.
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