Thrombospondin-1 Peptide Antigen
Cat.No. : | CDA101 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CDA101 |
Discription : | Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, and growth are attributed to TSP1. Recently, thrombospondin-1 was found to bind to the reelin receptors, ApoER2 and VLDLR, in so doing affecting neuronal migration in the rostral migratory stream. |
Sequence : | EDANLIPPVPDDKFC‐OH |
Physical Appearance : | White lyophilized powder |
Purity : | Peptide Purity>85% by HPLC |
Storage : | store at Freezer(‐20℃) immediately upon arrival. |
Synonyms : | TSP; THBS; TSP1; TSP-1; THBS-1; THBS1; thrombospondin 1; thrombospondin-1p180 |
Synonyms : | TSP; THBS; TSP1; TSP-1; THBS-1; THBS1; thrombospondin 1; thrombospondin-1p180 |
Products Types
◆ Recombinant Protein | ||
THBS1-894H | Recombinant Human THBS1 Protein, MYC/DDK-tagged | +Inquiry |
THBS1-355H | Recombinant Human THBS1 Protein, His-tagged | +Inquiry |
Thbs1-10619M | Recombinant Mouse Thbs1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Thbs1-6407M | Recombinant Mouse Thbs1 Protein, Myc/DDK-tagged | +Inquiry |
THBS1-2189H | Recombinant Human THBS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
THBS1-4946H | Native Human Thrombospondin protein | +Inquiry |
THBS1-5524H | Natve Human Thrombospondin | +Inquiry |
THBS1-31515TH | Native Human THBS1 | +Inquiry |
◆ Lysates | ||
THBS1-1101HCL | Recombinant Human THBS1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTHBS1 is widely expressed but is upregulated in response to injury or in certain disease states.
It can either promote or inhibit cancer progression, depending on the context.
It binds to extracellular matrix components, influencing cell attachment and signaling.
THBS1 acts as an angiogenesis inhibitor, hindering new blood vessel formation.
Therapeutic strategies include targeting THBS1 to modulate its effects in cancer and wound healing.
THBS1 modulates cell adhesion, proliferation, and migration.
Genetic variations in THBS1 have been linked to cardiovascular diseases and cancer risk.
Customer Reviews (3)
Write a reviewQuality exceeded my expectations.
Satisfied customer, will return.
Very pure, excellent results.
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