Recombinant Bovine PRKAR1A PRKAR1A-610B

Recombinant Bovine PRKAR1A


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Recombinant Bovine PRKAR1A

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Cat. No. : PRKAR1A-610B
Product Overview : Recombinant Bovine PRKAR1A is produced inE. coli.MW=43kDa.
Description : cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans.
Source : E. coli.
Purity : ≥95% (SDS-PAGE).
Formulation : Liquid. In 10mM potassium phosphate, pH 6.8, containing 150mM NaCl, 14mM 2-mercaptoethanol, 1mM EDTA and 50% glycerol.
Storage And Stability : -80°C. Keep the glycerol stock solution of the enzyme permanently at -20°C while pipetting to avoid loss of inhibitory activity. Avoid freeze/thaw cycles.
PDB rendering based on 1ne4. :

Gene Name : PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) [ Bos taurus ]
Synonyms : PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); cAMP-dependent protein kinase, regulatory subunit alpha 1; cAMP-dependent protein kinase type I-alpha regulatory subunit; EC
Gene ID : 615074
mRNA Refseq : NM_001076358
Protein Refseq : NP_001069826
UniProt ID : P00514
Chromosome Location : 19
Pathway : Apoptosis; Insulin signaling pathway
Function : cAMP binding; cAMP-dependent protein kinase regulator activity; kinase activity; nucleotide binding; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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