Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CADM3 protein, His-tagged

Cat.No. : CADM3-2184H
Product Overview : Recombinant Human CADM3 (Asn25-His330) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : Cell adhesion molecule 3 (CADM3) is also known as Synaptic cell adhesion molecule 3 (SynCAM3), Immunoglobulin superfamily member 4B (IgSF4B), Brain immunoglobulin receptor (BIgR), Nectin-like protein 1 (NECL-1), TSLC1-like protein 1 (TSLL1), which belongs to the nectin family. CADM3 contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.The isoform 1 is expressed mainly in adult and fetal brain and isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 involved in the cell-cell adhesion and has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. CADM3 / SynCAM3 interaction with EPB41L1 may regulate structure or function of cell-cell junctions.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Asn25
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 34.5 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Asn25-His330
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : CADM3
Official Symbol : CADM3
Synonyms : CADM3; cell adhesion molecule 3; IGSF4B, immunoglobulin superfamily, member 4B; BIgR; FLJ10698; Necl 1; NECL1; nectin like 1; SynCAM3; TSLL1; TSLC1-like 1; nectin-like 1; TSLC1-like protein 1; nectin-like protein 1; brain immunoglobulin receptor; synaptic cell adhesion molecule 3; immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; dendritic cell nectin-like protein 1 short isoform; IGSF4B; Necl-1; synCAM3
Gene ID : 57863
mRNA Refseq : NM_001127173
Protein Refseq : NP_001120645
MIM : 609743
UniProt ID : Q8N126

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the implications of CADM3 mutations or dysregulation in neurological diseases like autism or schizophrenia? 07/29/2022

Mutations or dysregulation of CADM3 have been linked to neurological disorders like autism spectrum disorders and schizophrenia, highlighting its significance in neural function.

Can you explain the structure of CADM3 and its interactions with other proteins or ligands in neural adhesion processes? 09/20/2021

CADM3 has extracellular domains responsible for adhesion. It interacts with other synaptic proteins like neurexins and neuroligins, contributing to synaptic adhesion and signaling.

How does CADM3 contribute to synaptic adhesion and plasticity, and why is this important for neurological research? 06/12/2020

CADM3 mediates synaptic adhesion and facilitates synaptic plasticity, which is essential for learning and memory processes. Understanding CADM3's role is critical for advancing our knowledge of neurological disorders and cognitive function.

What is the primary function of CADM3 in cellular processes, and where is it typically expressed in the body? 02/03/2019

CADM3, also known as SynCAM3, is a cell adhesion molecule that plays a crucial role in synapse formation and neural connectivity. It is primarily expressed in neural tissues, particularly in neurons.

How does CADM3 expression change during brain development, and what roles does it play in neural differentiation and circuit formation? 11/09/2018

CADM3 expression varies during brain development and contributes to neural differentiation and circuit formation, aiding in proper brain function.

Customer Reviews (3)

Write a review
Reviews
08/04/2022

    The product's quality is exceptional.

    03/21/2020

      I couldn't be happier with the results I've seen.

      01/27/2018

        it's helped me achieve my fitness goals faster than I expected.

        Ask a Question for All CADM3 Products

        Required fields are marked with *

        My Review for All CADM3 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends