Recombinant Mouse Tumor Necrosis Factor, FLAG-tagged

Cat. No.: Tnf-429M
Product Overview: Recombinant Mouse Tnf was produced inE. coli.The extracellular domain of mouse TNF-α (aa 77-235) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag.
Description: Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.The primary role of TNF is in the regulation of immune cells. TNF is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF production has been implicated in a variety of human diseases, as well as cancer. Recombinant TNF is used as an immunostimulant under the INN tasonermin.
Source: E. coli.
Purity: ≥95% (SDS-PAGE).
Concentration: 1mg/ml after reconstitution.
Formulation: Lyophilized. Contains PBS.
Specificity: TNF-α binds to human, mouse and rat TNF-R1 and TNF-R2. In the presence of cross-linking enhancer TNF-α preferentially binds to human, mouse and rat TNF-R2.
Reconstitution: Reconstitute the contents of each tube with 50µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
Stability: Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles.
Gene Name: Tnf tumor necrosis factor [ Mus musculus ]
Synonyms: Tnf; tumor necrosis factor; DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; MGC151434; TNF-alpha; TNF-a; TNF alpha; cachectin; tumor necrosis factor alpha; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2
Gene ID: 21926
mRNA Refseq: NM_013693
Protein Refseq: NP_038721
UniProt ID: P06804
Chromosome Location: 17 B1; 17 19.06 cM
Pathway: Adipocytokine signaling pathway; Allograft rejection; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Asthma; Chagas disease; Cytokine-cytokine receptor interaction; Dilated cardiomyopathy; Fc epsilon RI signaling pathway; Graft-versus-host disease; Hematopoietic cell lineage; Hypertrophic cardiomyopathy (HCM); Leishmaniasis; MAPK signaling pathway; NOD-like receptor signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Systemic lupus erythematosus; T cell receptor signaling pathway; TGF-beta signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus; Type II diabetes mellitus
Function: cytokine activity; protein binding; tumor necrosis factor receptor binding

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