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Recombinant Human KIT Ligand

Cat.No. : KITLG-436H
Product Overview : Recombinant Human KIT Ligand is expressed inDrosophila S2 insect cells.
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  • Gene Information
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Cat. No. : KITLG-436H
Description : Stem cell factor (SCF, kit ligand) is a type I membrane glycoprotein with 5 potential N-linked glycosylation sites. Soluble SCF is produced by proteolytic cleavage of the ECD. SCF is expressed primarily by fibroblasts however expression has also been detected in keratinocytes, mature granulocytes, Sertoli cells and bone marrow stromal cells. Functionally, SCF is involved in steady state maintenance of hematopoiesis and mediates the proliferation of myeloid, erythroid and lymphoid progenitors in bone marrow cultures. It has been shown to act synergistically with colony stimulating factors such as G-CSF and erythropoietin as well as interleukins. SCF is also involved in gametogenesis, melanogenesis and the membrane bound form of SCF mediates cell-cell adhesion.
Source : Drosophila S2 insect cells.
Concentration : 0.105 mg/ml.
Molecular Weight : The methionyl form of the S2 expressed mature human SCF contains 188 amino acid residues (including a C-terminal His6-tag) and has a molecular mass of 21 kDa.
Purity : ≥ 95%, as determined by SDS-PAGE.
Endotoxin Level : < 0.1 ng per 1 μg (< 1000 EU/mg), as determined by LAL gel clot test.
Biosafety : The manufacturing process includes the following two steps: Chemical inactivation of potential viruses (solvent/detergent inactivation); Virus removal through nanofiltration.
Formulation : Lyophilized from a protein solution in PBS without any carrier materials and preservatives.
Storage : -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Gene Name : KITLG KIT ligand [ Homo sapiens ]
Synonyms :
KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; DKFZp686F2250; KITLG; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; C-kit ligand; Mast cell growth factor; Stem cell factor
Gene ID : 4254
mRNA Refseq : NM_000899
Protein Refseq : NP_000890
MIM : 184745
UniProt ID : P21583
Chromosome Location : 12q22
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Melanogenesis; Pathways in cancer
Function : growth factor activity; identical protein binding; stem cell factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does KITLG influence stem cell factor (SCF) signaling pathways? 11/10/2022

Overexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.

What are the implications of KITLG in oncogenesis and tumor progression? 07/20/2022

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

What role does KITLG play in melanogenesis and pigmentation? 01/17/2022

Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.

Are there any known disorders associated with mutations or dysregulation of KITLG? 06/22/2020

Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.

What is the primary biological function of KITLG in the hematopoietic system? 04/12/2020

KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.

How has KITLG been explored as a therapeutic target or agent in clinical settings? 02/10/2020

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

How does KITLG interact with its receptor, c-KIT? 12/21/2019

KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.

Customer Reviews (3)

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Reviews
01/23/2022

    Reliable for immunoprecipitation assay.

    03/01/2021

      No contamination, very clean.

      02/09/2020

        Worked perfectly in Western.

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