|Official Full Name||KIT ligand|
|Background||This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins.|
|Synonyms||KITLG; KIT ligand; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; c-Kit ligand; steel factor; stem cell factor; mast cell growth factor; familial progressive hyperpigmentation 2; Clo; Con; Gb; SLF; Sl; contrasted; cloud gray; grizzle-belly; hematopoietic growth factor KL; stem cell factor Location: 10 51.4 cM|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
kitlg involved in several pathways and played different roles in them. We selected most pathways kitlg participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with kitlg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ras signaling pathway||FOXO4; ABL1; PLA2G2E; FGF22; RASA1; PIK3R3; NFKB1; GNGT1; PLCG2; KSR1|
|Rap signaling pathway||RAPGEF1; FGF1; GRIN2A; FYB; FGFR4; PFN2; CDC42; GNAI3; FGF21; PGF|
|Cytokine-cytokine receptor interaction||LEPR; XCL2; TGFB1; IL4; BMPR2; TNFSF18; CX3CL1; IFNPHI1; TSLP; TGFBR1|
|Phospholipase D signaling pathway||GAB1; GRM2; PLD1; PIP5K1A; PDGFRB; GRB2; PLA2G4D; PLA2G4A; GRM8; PPAP2A|
|PIK-Akt signaling pathway||Itga10&Itgb1; CCNE2; IFNA16; PDGFC; MLST8; FGF17; INSR; RPS6; LAMA1; IGF1R|
|Hematopoietic cell lineage||CD9; CD14; ITGA1; DNTT; CD3G; GP9; IL4; IL11RA; CD1D; EPOR|
|Melanogenesis||WNT8A; FZD3; WNT11; MAP2K2B; KITLGA; CALML3; GSK3B; ADCY2B; CAMK2G; FZD8B|
|Pathways in cancer||CCNE1; Kitl; Pdgfa&Pdgfb; PLCB3; IGF1; MMP2; GNG12; BIRC5; MTOR; WNT11|
kitlg has several biochemical functions, for example, cytokine activity, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by kitlg itself. We selected most functions kitlg had, and list some proteins which have the same functions with kitlg. You can find most of the proteins on our site.
|cytokine activity||GDF10B; GPI; GDF6B; TNFSF13B; LTB; IFNA17; IL17A/F3; IL4; CSF1A; CXCL9|
|growth factor activity||IL8L2; CSF3; Fgf15; TYMP; COL20A1; FGF20A; IL10; FGF14; FGF9; MIA1|
|protein binding||ID2; BCL2L2; RAD23A; CTGF; BRE; C1QL1; TFDP2; BET1; AXIN1; CNIH4|
|stem cell factor receptor binding||KITLGB; SPRED1; Kitl; SPRED2; KITLG; KITLGA|
kitlg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kitlg here. Most of them are supplied by our site. Hope this information will be useful for your research of kitlg.