Cat. No. : | CHP-2583H |
Product Overview : | Recombinant human CHP, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. |
Description : | CHP (Calcium-binding protein P22) is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity. |
Source : | E.coli. |
Sequences : | MGSSHHHHHH SSGLVPRGSH MMGSRASTLL RDEELEEIKK ETGFSHSQIT RLYSRFTSLD KGENGTLSRE DFQRIPELAI NPLGDRIINA FFPEGEDQVN FRGFMRTLAH FRPIEDNEKS KDVNGPEPLN SRSNKLHFAF RLYDLDKDEK ISRDELLQVL RMMVGVNISD EQLGSIADRT IQEADQDGDS AISFTEFVKV LEKVDVEQKM SIRFLH. |
Molecular Weight : | 24.7 kDa(216aa), confirmed by MALDI-TOF. |
Form : | Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 10% Glycerol. |
Purity : | > 95% by SDS – PAGE. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | CHP calcium binding protein P22 [ Homo sapiens ] |
Synonyms : | CHP; lcium binding protein P22; calcium-binding protein p22; calcineurin B homolog; SLC9A1 binding protein; calcium-binding protein CHP; calcineurin homologous protein |
Gene ID : | 11261 |
mRNA Refseq : | NM_007236 |
Protein Refseq : | NP_009167 |
MIM : | 606988 |
UniProt ID : | Q99653 |
Chromosome Location : | 15q13.3 |
Pathway : | Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Axon guidance; B cell receptor signaling pathway; Long-term potentiation; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Oocyte meiosis; T cell receptor signaling pathway; VEGF signaling pathway; Wnt signaling pathway |
Function : | calcium ion binding; potassium channel regulator activity |
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