Cat. No.:	CHP-2583H
Product Overview:	Recombinant human CHP, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.
Description:	CHP (Calcium-binding protein P22) is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.
Source:	E.coli.
Sequences:	MGSSHHHHHH SSGLVPRGSH MMGSRASTLL RDEELEEIKK ETGFSHSQIT RLYSRFTSLD KGENGTLSRE DFQRIPELAI NPLGDRIINA FFPEGEDQVN FRGFMRTLAH FRPIEDNEKS KDVNGPEPLN SRSNKLHFAF RLYDLDKDEK ISRDELLQVL RMMVGVNISD EQLGSIADRT IQEADQDGDS AISFTEFVKV LEKVDVEQKM SIRFLH.
Molecular Weight:	24.7 kDa(216aa), confirmed by MALDI-TOF.
Form:	Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 10% Glycerol.
Purity:	> 95% by SDS – PAGE.
Concentration:	1 mg/ml (determined by Bradford assay).
Storage:	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Name:	CHP calcium binding protein P22 [ Homo sapiens ]
Synonyms:	CHP; lcium binding protein P22; calcium-binding protein p22; calcineurin B homolog; SLC9A1 binding protein; calcium-binding protein CHP; calcineurin homologous protein
Gene ID:	11261
mRNA Refseq:	NM_007236
Protein Refseq:	NP_009167
MIM:	606988
UniProt ID:	Q99653
Chromosome Location:	15q13.3
Pathway:	Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Axon guidance; B cell receptor signaling pathway; Long-term potentiation; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Oocyte meiosis; T cell receptor signaling pathway; VEGF signaling pathway; Wnt signaling pathway
Function:	calcium ion binding; potassium channel regulator activity

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