Recombinant Human Catenin, Beta Interacting Protein 1, His-tagged CTNNBIP1-2585H

Recombinant Human Catenin, Beta Interacting Protein 1, His-tagged

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Recombinant Human Catenin, Beta Interacting Protein 1, His-tagged

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Cat. No. : CTNNBIP1-2585H
Product Overview : Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.
Description : CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene.
Source : E.coli.
Sequences : MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q.
Molecular Weight : 11.3kDa (101a) confirmed by MALDI-TOF.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 2mM DTT, 100mM NaCl.
Purity : > 90% by SDS – PAGE.
Concentration : 1mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1luj. :

Gene Name : CTNNBIP1 catenin, beta interacting protein 1 [ Homo sapiens ]
Synonyms :
CTNNBIP1; catenin, beta interacting protein 1; OTTHUMP00000001722; beta-catenin-interacting protein 1; beta-catenin-interacting protein ICAT; catenin, beta-interacting protein 1; inhibitor of beta-catenin and Tcf-4; RP11-84A14.1; ICAT; MGC15093
Gene ID : 56998
mRNA Refseq : NM_001012329
Protein Refseq : NP_001012329
MIM : 607758
UniProt ID : Q9NSA3
Chromosome Location : 1p36.22
Pathway : Wnt signaling pathway
Function : beta-catenin binding; otein binding

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