|Product Overview:||Recombinant Human CARD14 was produced inE.coliwith a T7 tag at N-terminus. MW = 113300 Da (1-434 aa).|
|Description:||The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.|
|Form:||10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3.|
|Gene Name:||CARD14 caspase recruitment domain family, member 14 [ Homo sapiens ]|
|Synonyms:||CARD14; caspase recruitment domain family, member 14; BIMP2; CARMA2; caspase recruitment domain-containing protein 14; carma 2; card-maguk protein 2; CARD-containing MAGUK 2 protein; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2; Carma 2|
|Function:||CARD domain binding; protein binding|
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