Recombinant Human CRTAM protein, His-tagged
Cat.No. : | CRTAM-3236H |
Product Overview : | Recombinant Human CRTAM (Ser18-Gly287) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser18 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 31.9 kDa. The protein migrates as 42-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Ser18-Gly287 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
Gene Name : | CRTAM |
Official Symbol : | CRTAM |
Synonyms : | CRTAM; cytotoxic and regulatory T cell molecule; cytotoxic and regulatory T-cell molecule; CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule |
Gene ID : | 56253 |
mRNA Refseq : | NM_019604 |
Protein Refseq : | NP_062550 |
MIM : | 612597 |
UniProt ID : | O95727 |
Products Types
◆ Recombinant Protein | ||
CRTAM-47H | Recombinant Human CRTAM Protein, His (Fc)-Avi-tagged | +Inquiry |
CRTAM-775C | Recombinant Cynomolgus monkey CRTAM Protein, Fc-tagged | +Inquiry |
CRTAM-1913H | Recombinant Human CRTAM Protein, GST-tagged | +Inquiry |
CRTAM-119H | Recombinant Human CRTAM Protein, C-His-tagged | +Inquiry |
CRTAM-1912H | Recombinant Human CRTAM Protein | +Inquiry |
◆ Lysates | ||
CRTAM-2216HCL | Recombinant Human CRTAM cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All CRTAM Products
Required fields are marked with *
My Review for All CRTAM Products
Required fields are marked with *
0
Inquiry Basket