Recombinant Human Geranylgeranyl Diphosphate Synthase 1, His-tagged
Cat.No. : | GGPS1-2800H |
Product Overview : | Recombinant human GGPS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 37 kDa (320aa), confirmed by MALDI-TOF. |
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- Gene Information
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Cat. No. : | GGPS1-2800H |
Description : | Geranylgeranyl pyrophosphate synthase isoform A, also known as GGPS1, is a member of the prenyltransferase family. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. |
Source : | E.coli. |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE |
Purity : | > 90% by SDS – PAGE. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol. |
Concentration : | 1mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ] |
Synonyms : | GGPS1; geranylgeranyl diphosphate synthase 1; GGPPS; GGPPS1; geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; OTTHUMP00000216161; OTTHUMP00000216162; OTTHUMP00000216163; OTTHUMP00000216164; EC 2.5.1.1; EC 2.5.1.10; EC 2.5.1.29; Dimethylallyltranstransferase; Geranyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase |
Gene ID : | 9453 |
mRNA Refseq : | NM_001037277 |
Protein Refseq : | NP_001032354 |
MIM : | 606982 |
UniProt ID : | O95749 |
Chromosome Location : | 1q43 |
Pathway : | Metabolic pathways; Terpenoid backbone biosynthesis |
Function : | dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity |
Products Types
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GGPS1-980H | Recombinant Human GGPS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
GGPS1-361H | Recombinant Human GGPS1 Protein, Myc/DDK-tagged | +Inquiry |
GGPS1-0283H | Recombinant Human GGPS1 Protein (M1-E300), His/Strep tagged | +Inquiry |
◆ Lysates | ||
GGPS1-5946HCL | Recombinant Human GGPS1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGGPS1 is involved in protein prenylation, essential for the function of many proteins.
GGPS1 works in tandem with other enzymes involved in cholesterol and lipid metabolism.
Genetic mutations in GGPS1 can lead to changes in lipid metabolism and synthesis.
Altered GGPS1 activity affects the production of important lipid compounds, impacting cell function.
It plays a role in cholesterol biosynthesis by providing precursors necessary for the process.
GGPS1, Geranylgeranyl Pyrophosphate Synthase 1, is crucial for synthesizing geranylgeranyl pyrophosphate, a key intermediate in lipid metabolism.
Targeting GGPS1 offers potential treatments for disorders related to lipid metabolism.
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