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Recombinant Human Geranylgeranyl Diphosphate Synthase 1, His-tagged

Cat.No. : GGPS1-2800H
Product Overview : Recombinant human GGPS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 37 kDa (320aa), confirmed by MALDI-TOF.
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Cat. No. : GGPS1-2800H
Description : Geranylgeranyl pyrophosphate synthase isoform A, also known as GGPS1, is a member of the prenyltransferase family. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
Concentration : 1mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : GGPS1 geranylgeranyl diphosphate synthase 1 [ Homo sapiens ]
Synonyms : GGPS1; geranylgeranyl diphosphate synthase 1; GGPPS; GGPPS1; geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; OTTHUMP00000216161; OTTHUMP00000216162; OTTHUMP00000216163; OTTHUMP00000216164; EC 2.5.1.1; EC 2.5.1.10; EC 2.5.1.29; Dimethylallyltranstransferase; Geranyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase
Gene ID : 9453
mRNA Refseq : NM_001037277
Protein Refseq : NP_001032354
MIM : 606982
UniProt ID : O95749
Chromosome Location : 1q43
Pathway : Metabolic pathways; Terpenoid backbone biosynthesis
Function : dimethylallyltranstransferase activity; farnesyltranstransferase activity; geranyltranstransferase activity; metal ion binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does GGPS1 play in protein prenylation? 12/28/2022

GGPS1 is involved in protein prenylation, essential for the function of many proteins.

How does GGPS1 interact with other enzymes in cholesterol metabolism? 02/25/2022

GGPS1 works in tandem with other enzymes involved in cholesterol and lipid metabolism.

How do genetic variations in GGPS1 affect its enzymatic activity? 12/22/2020

Genetic mutations in GGPS1 can lead to changes in lipid metabolism and synthesis.

What is the impact of altered GGPS1 activity on lipid synthesis? 11/18/2019

Altered GGPS1 activity affects the production of important lipid compounds, impacting cell function.

How does GGPS1 contribute to cholesterol biosynthesis? 05/13/2018

It plays a role in cholesterol biosynthesis by providing precursors necessary for the process.

What is the primary role of GGPS1 in cellular metabolism? 02/12/2018

GGPS1, Geranylgeranyl Pyrophosphate Synthase 1, is crucial for synthesizing geranylgeranyl pyrophosphate, a key intermediate in lipid metabolism.

What potential therapeutic applications arise from targeting GGPS1? 10/08/2017

Targeting GGPS1 offers potential treatments for disorders related to lipid metabolism.

Customer Reviews (3)

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Reviews
09/23/2021

    Key contributor to discoveries. Valuable research partner.

    01/29/2020

      Trusted for research integrity. Supports our projects effectively.

      06/08/2019

        Efficient and dependable. Elevates our research standards.

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