Recombinant Rat Tnfsf11

• Cat.No.: Tnfsf11-2680R
• Product Overview: Recombinant rat Tnfsf11 is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues). It is expressed inE. coli.

Specification

• Cat. No.: Tnfsf11-2680R
• Description: RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a molecule important in bone metabolism. This natural and necessary surface-bound molecule found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.
• Source: E. coli.
• Purity: Greater than 98% (determined by SDS-PAGE and HPLC analysis).
• MW: 19.4 kDa.
• Endotoxin Level: < 0.1 ng per μg of rHu APO-E4 (1EU/μg).
• Formulation: Lyophilized from a sterile-filtered solution with no additives.
• Reconstitution: Please Note: Always centrifuge product before opening vial. The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further dilution, carrier protein (0.1% BSA or HSA) should be added to avoid loss of bioactivity.
• Storage: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Rattus norvegicus ]
• Synonyms:
  Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11; ODF; OPGL; TNF-related activation-induced cytokine; TRANCE; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11; RANKL
• Gene ID: 117516
• mRNA Refseq: NM_057149
• Protein Refseq: NP_476490
• UniProt ID: Q9ESE2
• Chromosome Location: 15q11
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity; protein binding; tumor necrosis factor receptor binding; receptor activity