Recombinant Human Vitronectin

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Recombinant Human Vitronectin

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Cat. No. : VTN-2709H
Product Overview : Recombinant Human Vitronectin is expressed inhuman cell line.
Description : Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin consists of three domains: the N-terminal Somatomedin B domain, a central domain with hemopexin homology, and a C-terminal domain also with hemopexin homology. The Somatomedin B domain is a close knit disulfide knot and binds to plasminogen activator inhibitor-1 (PAI-1) and stabilizes it. An RGD sequence which is a binding site for membrane bound integrins is also found in Vitronectin. As a component of platelets, Vitronectin serves to regulate proteolysis initiated by plasminogen activation, interacts with the urokinase receptor, and binds to several serpin serine protease inhibitors as well. Accordingly, Vitronectin is suggested to be.
Source : produced serum-free in a human cell line.
Purification : by affinity chromatography.
Storage Buffer : 20 mM Tris, 200 mM NaCl, pH 7.5.
Purity : > 95% (SDS-PAGE). HMS > 800 kDa, reduced dimer at 120 kDa, monomer at 65 kDa.
Identity : Immuno-Blot with specific polyclonal antiserum .
Activity : tested in a cell attachment and spreading assay.
Contents : 250 µg / 1mg (lyophilized). Resuspend in aqua bidest for required concentration.
Store At : 2-8 °C (lyophilized); - 20 °C (dissolved). Repeated thawing and freezing must be avoided.
The SMB domain (yellow) in complex with PAI-1. :

Gene Name : VTN vitronectin [ Homo sapiens ]
Synonyms : VTN; vitronectin; VN; V75; VNT; epibolin; somatomedin B; complement S-protein; serum spreading factor; vitronectin (serum spreading factor, somatomedin B, complement S-protein); Serum-spreading factor
Gene ID : 7448
mRNA Refseq : NM_000638
Protein Refseq : NP_000629
MIM : 193190
UniProt ID : P04004
Chromosome Location : 17q11
Pathway : ECM-receptor interaction; Focal adhesion
Function : extracellular matrix binding; heparin binding; polysaccharide binding; protein binding; scavenger receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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