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Recombinant Human RARB, His-tagged

Cat. No.: RARB-2511H
Product Overview: Recombinant human His-tagged RAR-β was expressed in abaculovirussystem and purified by affinity and FPLC chromatography. 55 kDa.
Description: Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer cells, breast cancer cells, the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors. They have previously been used as chemoprevention agents against both types of cancer. A growing body of evidence supports the hypotheses that the RAR- β gene is a tumor suppressor gene and the chemopreventive effects of retinoids are due to induction of RAR-β. RAR-β expression is reduced in many malignant tumors including breast carcinoma.
Source: baculovirus.
Applications: RAR-β has been applied to in vitro transcription assays, DNA and protein-protein interaction assays.
Transcript Variant: This variant encodes the full length isoform.
Activity: 1 unit is equal to 1 nanogram of purified protein. 20-100 units are sufficient for an in vitro transcription assay and 100 units are sufficient for a protein-protein interactions assay.
Quality Control: The purified protein is greater than 95% homogeneous based on SDS-PAGE gel analysis.
Reagents Supplied: 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
Storage Conditions: Store at -80°C.
Pathways: Non-small cell lung cancer; Pathways in cancer; Small cell lung cancer
Gene Name: RARB retinoic acid receptor, beta [ Homo sapiens ]
Synonyms: retinoic acid receptor, beta; HAP; RRB2; NR1B2; RARB; RAR-epsilon; RAR-beta; OTTHUMP00000161046; HBV-activated protein; retinoic acid receptor beta 2; retinoic acid receptor beta 4; retinoic acid receptor beta 5; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; RAR-epsilon; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2
Gene ID: 5915
mRNA Refseq: NM_000965
Protein Refseq: NP_000956
MIM: 180220
UniProt ID: P10826
Chromosome Location: 3p24
Function: metal ion binding; retinoic acid receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; transcription activator activity; transcription factor activity; zinc ion binding

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