Human RARB Knockdown Cell Lysate

• Cat.No.: RARB-417HKCL
• Product Overview: WB-validated RARB Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 50 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg RARB KD HeLa cell lysate
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: RARB retinoic acid receptor, beta [ Homo sapiens (human) ]
• Official Symbol: RARB
• Synonyms: RARB; retinoic acid receptor, beta; retinoic acid receptor beta; HAP; NR1B2; RRB2; RAR-beta; RAR-epsilon; HBV-activated protein; retinoic acid receptor beta 2; retinoic acid receptor beta 4; retinoic acid receptor beta 5; hepatitis B virus activated protein; retinoic acid receptor beta variant 1; retinoic acid receptor beta variant 2; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2; MGC97363
• Gene ID: 5915
• mRNA Refseq: NM_000965
• Protein Refseq: NP_000956
• MIM: 180220
• UniProt ID: P10826