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Recombinant Human Angiopoietin 1

Cat. No.: ANGPT1-2518H
Description: The Angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation. Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase. The factor enhances endothelial cell survival and capillary morphogenesis, and also limits capillary permeability. Ang-2 binds the same receptor but fails to activate it: hence, it is a natural inhibitor of Ang-1. Ang-2 destabilizes capillary integrity, facilitating sprouting when ambient vascular endothelial growth factor (VEGF) levels are high, but causing vessel regression when VEGF levels are low. Tie-1 is a Tie-2 homologue but its ligands are unknown. Angiopoietin and Tie genes are expressed in the mammalian metanephros, the precursor of the adult kidney, where they may play a role in endothelial precursor growth. Tie-1-expressing cells can be detected in the metanephros when it first forms and, based on transplantation experiments, these precursors contribute to the generation of glomerular capillaries. During glomerular maturation, podocyte-derived Ang-1 and mesangial-cell-derived Ang-2 may affect growth of nascent capillaries.
Source: mouse NSO cells.
Analysis Note: The biological activity is measured by its ability to inhibit serum deprivation induced apoptosis in HUVE cells.
Biochem/physiol Actions: Ang-1 is a ligand with affinity to the Tie-2 receptor tyrosine kinase, which is expressed in early hematopoietic and endothelial cells. Both Ang-1 and Tie-2 play critical roles in embryonic angiogenesis as well as adult vascular integrity.
Physical Form: Lyophilized from a 0.2 μm filtered solution in 50 mM Tris and 0.5 M sodium chloride, pH 6.5, containing 50 μg bovine serum albumin per 1 μg of cytokine.
Assay: ≥90% (SDS-PAGE).
Storage Temp: −20°C.
Pathways: Hemostasis; Signaling in Immune system
Gene Name: ANGPT1 angiopoietin 1 [ Homo sapiens ]
Synonyms: ANGPT1; angiopoietin 1; AGP1; AGPT; ANG1; KIAA0003, Ang1; Angiopoietin-1; ANG-1
Gene ID: 284
mRNA Refseq: NM_001146
Protein Refseq: NP_001137
MIM: 601667
UniProt ID: Q15389
Chromosome Location: 8q23.1
Function: receptor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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