Recombinant Human Ring Finger Protein 11

• Cat.No.: RNF11-2534H

Specification

• Cat. No.: RNF11-2534H
• Description: RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene. The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).
• Source: E.coli.
• Biochem/physiol Actions: RNF11 (RING Finger Protein 11) is a RING E3 ubiquitin ligase with potential to mediate ubiquitination and subsequent proteolysis.1,2 RNF11 binds numerous proteins in a variety of cellular pathways, including TGFβ and EGFR signaling.3,1,2 RNF11 expression is elevated in breast and prostate cancer. RNF11 may represent an important target for novel cancer therapies.
• Physical Form: Solution in 50 mM Tris, pH 7.5, 150 mM NaCl, 1 mM DTT, and 30% glycerol (w/v).
• Assay: ≥90% (SDS-PAGE).
• Form: buffered aqueous solution.
• Storage Temp: −20°C.

Gene Information

• Gene Name: RNF11 ring finger protein 11 [ Homo sapiens ]
• Synonyms: ring finger protein 11; CGI-123; SID1669; MGC51169; RNF11; RING finger protein 11;Sid1669p; Sid 1669
• Gene ID: 26994
• mRNA Refseq: NM_014372
• Protein Refseq: NP_055187
• MIM: 612598
• UniProt ID: Q9Y3C5
• Chromosome Location: 1pter-p22.1
• Function: DNA binding; metal ion binding; protein binding; zinc ion binding