"Granzyme B" Related Products

Granzyme B Activity Fluorometric Assay Kit

Cat.No.: Kit-2268
Product Overview: Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. In Granzyme B Activity Assay Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500 nm. This Assay Kit is rapid, reliable and sensitive and can detect Granzyme B activity in various biological samples.
Applications: Measurement of Granzyme B activity in various biological samples or purified Granzyme B activity, Screening Granzyme B inhibitors, characterize/Study Granzyme B inhibitors.
Storage: -20°C
Shipping: Gel Pack
Size: 100 assays
Kit Components: Granzyme B Assay Buffer; Granzyme B Substrate; Positive Control (Granzyme B Enzyme, human recombinant); AFC Standard (1mM)
Detection method: Fluorescence (Ex/Em = 380/500 nm)
Features & Benefits: Simple and Sensitive;
Rapid and convenient;
Kit contains all necessary reagents for measuring Granzyme B Activity.

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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