Human Interferon alpha-2b (rDNA derived) Reference standard

• Cat.No.: INFA2b-148H
• Product Overview: This preparation is intended for use as the primary biological reference standard in bioassays for IFN- alpha 2b.

Specification

• Species: Human
• Enzyme Unit: 70, 000 International Units per ampoule.
• Usage: No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. Dissolve the total contents of the ampoule in 0.5ml of sterile distilled water and transfer to a sterile container. Rinse the ampoule with about 0.4ml of sterile distilled water and add to the first solution. Make up the total volume to 1.0ml with sterile distilled water. The final solution will contain IFN alpha 2b at a concentration of the 70000 International Units per ml. Use carrier protein where dilution is required.
• Notes: This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts.
• Stability: Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities and they should be stored on receipt as indicated on the label. Accelerated degradation studies have indicated that this material is suitably stable, when stored at -20°C or below, for the assigned values to remain valid until the material is withdrawn or replaced. These studies have also shown that the material is suitably stable for shipment at ambient temperature without any effect on the assigned values. Once reconstituted, diluted or aliquoted, users should determine the stability of the material according to their own method of preparation, storage and use. Users who have data supporting any deterioration in the characteristics of any reference preparation are encouraged to contact Creative Biomart.
• Storage: For economy of use, it is recommended that the final solution be sub- divided into several small aliquots and stored at -40°C or below. Avoid repeated thawing/freezing. Unopened ampoules should be stored at - 20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature.

Gene Information

• Gene Name: IFNA2 interferon, alpha 2 [ Homo sapiens ];
• Official Symbol: IFNA2
• Synonyms: IFNA; INFA2; IFNA2B; IFN-alphaA; interferon alpha-2; leIF A; IFN-alpha-2; interferon alpha A; alpha-2a interferon; interferon alpha 2a; interferon alpha 2b
• Gene ID: 3440
• mRNA Refseq: NM_000605
• Protein Refseq: NP_000596
• MIM: 147562
• UniProt ID: P01563
• Chromosome Location: 9p22
• Pathway: Autoimmune thyroid disease, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hepatitis C, conserved biosystem
• Function: cytokine activity; protein binding; type I interferon receptor binding

Reviews

11/14/2022

 The product’s adaptability to various buffers contributed to its stable and reliable performance.

08/12/2019

The product's exceptional purity facilitated precise quantification, ensuring data consistency.

10/29/2018

Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.

Q&As

Is INFA2B protein’s function essential for viral defense and immune homeostasis?

Yes, INFA2B protein’s function is essential for effective viral defense and maintaining immune system homeostasis.

Can INFA2B protein’s function affect viral pathogenesis and clearance?

Yes, INFA2B protein’s function significantly impacts viral pathogenesis and the clearance of infected cells.

Does INFA2B protein play a role in autoimmune diseases?

Dysregulation of INFA2B proteins can contribute to autoimmune diseases by promoting self-reactive immune responses.

How does INFA2B protein contribute to antiviral defenses across different cell types?

INFA2B proteins orchestrate antiviral defenses in various cell types, ensuring a robust response against viruses.

Can INFA2B protein’s activity influence the balance of pro-inflammatory and anti-inflammatory responses?

Yes, INFA2B protein’s function can modulate the balance between pro-inflammatory and anti-inflammatory signals during immune responses.

How is INFA2B protein’s involvement studied within the context of vaccination?

Research explores how INFA2B proteins may enhance the effectiveness of vaccines by boosting immune responses.

How does INFA2B protein’s role relate to adaptive immunity?

INFA2B proteins contribute to the early stages of immune responses, bridging innate and adaptive immunity.