|Description:||TDG is a DNA glycosylase that removes T from the TG mismatch in DNA. Such mismatch can derive from deamination of methylated C in DNA. TDG is a mono functional glycosylase that leaves an intact AP site in DNA following its glycosylase action. In addition to T, U or ethenoC opposite G is also recognized by TDG.|
|Form:||The protein is supplied in 20 mM sodium phosphate (pH 7.5), 150 mM NaCl, 5 mM β- mercaptoethanol, 10% glycerol.|
|Gene Name:||TDG thymine-DNA glycosylase [ Homo sapiens ]|
|Synonyms:||TDG; thymine-DNA glycosylase; G/T mismatch-specific thymine DNA glycosylase; EC 22.214.171.124|
|Pathway:||Base excision repair, conserved biosystem; Depyrimidination, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosyst|
|Function:||damaged DNA binding; mismatched DNA binding; protein binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity|
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