"TDG" Related Products

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Human TDG protein

Cat.No.: TDG-7443H
Description: TDG is a DNA glycosylase that removes T from the TG mismatch in DNA. Such mismatch can derive from deamination of methylated C in DNA. TDG is a mono functional glycosylase that leaves an intact AP site in DNA following its glycosylase action. In addition to T, U or ethenoC opposite G is also recognized by TDG.
Species: Human
Form: The protein is supplied in 20 mM sodium phosphate (pH 7.5), 150 mM NaCl, 5 mM β- mercaptoethanol, 10% glycerol.
Gene Name: TDG thymine-DNA glycosylase [ Homo sapiens ]
Official Symbol: TDG
Synonyms: TDG; thymine-DNA glycosylase; G/T mismatch-specific thymine DNA glycosylase; EC 3.2.2.29
Gene ID: 6996
mRNA Refseq: NM_003211
Protein Refseq: NP_003202
MIM: 601423
UniProt ID: Q13569
Chromosome Location: 12q24.1
Pathway: Base excision repair, conserved biosystem; Depyrimidination, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosyst
Function: damaged DNA binding; mismatched DNA binding; protein binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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