Matrix Metalloproteinase-12 (MMP-12) fluorometric drug discovery Kit

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Matrix Metalloproteinase-12 (MMP-12) fluorometric drug discovery Kit

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Cat.No. : Kit-0571
Product Overview : A QuantiZyme Assay System. The MMP-12 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-12, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
Size : 96 wells
Applications : Fluorescence microscopy, HTS
Storage : -80°C
Kit Components : MMP-12 enzyme (human) (recombinant), substrate, calibration standard, inhibitor, assay buffer, 96-well white microplate.

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