Metallothionein

• Cat.No.: COP03

Specification

• Source: Rabbit Liver
• Tag: Non
• Description: Metallothionein (MT) is a family of cysteine-rich, low molecular weight (MW ranging from 3500 to 14000 Da) proteins. MTs have the capacity to bind both physiological (Zn, Cu, Se...) and xenobiotic (Cd, Hg, Ag,...) heavy metals through the thiol group of its cysteine residues, which represents nearly the 30% of its amino acidic residues. MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding protein from horse (equine) renal cortex. Metallothionein function is not clear, but experimental data suggest MTs may provide protection against metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. Metallothionein gene expression is induced by a high variety of stimuli, as metal exposure, oxidative stress, glucocorticoids, hydric stress, etc. The level of the response to these inducers depends on the MT gene. There are four main metallothionein isoforms expressed in humans. In the human body, large quantities are synthesised primarily in the liver and kidneys. Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine. Biomart native rabbit metallothionein contains both form I and form II metallothionein Zinc content greater than 6%.
• M.W.: 6-7KDa
• Appearance: off-white lyophilized Powder
• Purity: greater than 90%
• Storage: Stored at 2-8℃
• Publications:
  Metals and Metallothioneins in Morelet’s Crocodile (Crocodylus moreletii) from a Transboundary River Between Mexico and Belize. (2015)
  Biomarcadores de efecto y exposición a metales pesados en Crocodylus moreletii, en el río Hondo (2014)
  Effects of selenium, zinc, insulin and metallothionein on cadmium-induced oxidative stress and metallothionein gene expression levels in diabetic rats (2020)
  Intracellular Zinc Trafficking: An Interplay of Proteome, Metallothioneine and Glutathione (2020)
  Metallothionein-I + II Reduces Oxidative Damage and Apoptosis after Traumatic Spinal Cord Injury in Rats (2018)
  The acute systemic toxicity of thallium in rats produces oxidative stress: attenuation by metallothionein and Prussian blue (2021)
  Synthetic fish metallothionein design as a potential tool for monitoring toxic metals in water (2021)
  Zinc trafficking 1. Probing the roles of proteome, metallothionein, and glutathione (2021)
  Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity (2021)
  Zinc trafficking to apo-Zn-proteins 2. Cellular interplay of proteome, metallothionein, and glutathione (2022)