Mouse Anti-Human MRP1 Monoclonal Antibody

• Cat.No.: CAB-905MH

Specification

• Species: Human
• Source: Mouse
• Tag: Non
• Specificity: Human multidrug resistanec-associated protein 1
• Clonality: Monoclonal
• Positive Control: Breast tumors
• Staining Pattern: Cytoplasmic, Cell membrane
• Specificity Note: The MRP molecule, an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein, is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.
• Applications: Formalin-fixed paraffin-embedded tissue, or IHC frozen sections. No antigen retrieval necessary.
• Recommended Usage: IHC test, research use only. Incubate with samples at RT for 60min or at 4℃ overnight.
• Storage: 2-8℃ for 12 months.

Gene Information

• Gene Name: MRP1 Multidrug resistance-associated protein-1 [ Homo sapiens ]
• Synonyms: MRP1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; MRP; multidrug resistance associated protein 1; GS-X; Leukotriene C(4) transporter; ATP-binding cassette sub-family C member 1; multidrug resistance-associated protein 1; multiple drug resistance-associated protein; ABC29; ABCC; DKFZp781G125; multiple drug resistance protein 1; DKFZp686N04233; multidrug resistance protein
• Gene ID: 4363
• mRNA Refseq: NM_004996.3
• Protein Refseq: NP_004987.2
• MIM: 158343
• UniProt ID: P33527
• Chromosome Location: 16p13.1
• Function: ATP binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;hydrolase activity;nucleotide binding;transporter activity