Native Agaricus bisporus lectin Protein, Biotinylated

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Native Agaricus bisporus lectin Protein, Biotinylated

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Cat.No. : Lectin-1762A
Product Overview : This product is the Biotinylated Agaricus bisporus lectin and has sugar specificity against Gal(b-1,5)GalNAc (T disaccharide).
Description : Agaricus bisporus lectin (ABL) isolated from the edible white button mushroom, is composed of two to four very similar isolectins, each a tetramer of approximately 17 kD subunits. This lectin binds the Thomsen-Friedenreich antigen, also called T disaccharide, galactosyl (β-1,3) N-acetylgalactosamine. Unlike peanut agglutinin, which does not bind sialylated T antigen, ABL binds either sialylated or asialylated forms. Also, whereas peanut agglutinin has a proliferative effect on cancer cells, ABL is anti-proliferative, apparently without cytotoxicity. ABL binds all blood groups and O-linked glycans of IgA subclasses. Simple mono- and disaccharides are only marginally inhibitory.
Source : Agaricus bisporus
Species : Agaricus bisporus
Form : 10 mM HEPES, pH 7.5, 150 mM NaCl, 0.08% sodium azide.
Bio-activity : Sugar Specificity: Gal(b-1,3)GalNAc (T disaccharide)
Applications : Immunohistochemistry; Immunocytochemistry; Immunofluorescence; Blotting Applications; Elispot; ELISAs; Glycobiology
Storage : Refrigerate in the dark.
Concentration : 2 mg/ml
Synonyms : Lectin; ABL
UniProt ID : Q00022

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