Native Elderberry Sambucus nigra Lectin (SNA/EBL I+II)

• Cat.No.: SNA/EBL I+II-703E
• Product Overview: Native Elderberry Sambucus nigra Lectin (SNA/EBL I+II) - Semi-Pure
  Preferred Sugar Specificity: Sialic Acid
  Inhibiting or Eluting Sugar: Lactose > β-Galactose
  Divalent Ions: None Required
  Mitogenic Activity: Yes
  Hazardous Shipping: Non-hazardous

Specification

• Species: Elderberry
• Source: Elderberry
• Description: Fractionated Sambucus nigra lectin (EBL I+II, also known as SNA) is is composed of two ricin-related lectins. EBL I+II is a tetrameric glycoprotein with a recognition of the Neu5Ac(?2-6)Gal or GalNAc linkage in glycoconjugates. EBL I is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. EBL II consists only of carbohydrate-binding B-chains. EBL I+II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems independent from the catalytic activity of the A-chain, but depends on the carbohydrate binding B-chain.
• Form: Powder
• Storage: At -20 centigrade.

Gene Information

• Official Symbol: SNA/EBL I+II
• Synonyms: Sambucus nigra Lectin; SNA/EBL I+II