Native Garlic Allium sativum Lectin (ASA), Ferritin-Conjugated

• Cat.No.: ASA-253G
• Product Overview: Native Garlic Allium sativum Lectin (ASA) - Ferritin
  Blood Group Specificity: Non-specific
  Preferred Sugar Specificity: Mannose
  Inhibiting or Eluting Sugar: α(1,3)-Linked Mannosyl Units
  Divalent Ions: None Required
  Hazardous Shipping: Non-hazardous

Specification

• Description: Allium sativum lectin (ASA) is purified first with affinity chromatography and then with gel filtration. The lectin recognizes internal mannose and binds to the core pentasaccharide of N-linked glycans. In addition, the removal of sialic acids enhances binding activity. Allium sativum Lectin (ASA) is conjugated to ferritin, that has a molecular weight of 474,000 g/mol (all 24 subunits combined). Ferritin-conjugated lectins can be used to visualize localization of specific saccharide moieties and examine the distribution of plasma membrane glycoproteins. These conjugates can be viewed via electron microscopy.
• Source: Garlic
• Species: Garlic
• Form: Liquid
• Purity: High Purity Grade
• Stability: Shelf Life: 1 year
• Storage: At 2-8 centigrade.
• Concentration: 1 mg/mL
• Official Symbol: ASA
• Synonyms: Allium sativum Lectin; ASA

Gene Information

• Official Symbol: ASA
• Synonyms: Allium sativum Lectin; ASA

Reviews

05/01/2021

With their extensive knowledge and expertise, I am assured that any challenges or issues I may encounter during my research will be efficiently resolved.

10/01/2017

I am highly impressed with the ASA protein as it is of exceptionally high quality, and I am confident that it will perfectly meet the specific requirements of my experiments.

12/14/2016

Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.

Q&As

How does the ASA protein contribute to the urea cycle?

The ASA protein cleaves argininosuccinate into arginine and fumarate, allowing arginine to continue through the urea cycle and fumarate to enter other metabolic pathways.

What are the symptoms of argininosuccinic aciduria?

Symptoms of argininosuccinic aciduria include developmental delay, vomiting, seizures, liver dysfunction, elevated ammonia levels, and intellectual disability if left untreated.

Where is the ASA protein predominantly expressed?

The ASA protein is primarily expressed in the liver, but it can also be found in other tissues such as the kidneys and intestines.

Are there any genetic variations in the ASA gene?

Yes, genetic variations in the ASA gene can lead to different forms of argininosuccinic aciduria, with varying severity and clinical presentations.

How is the ASA protein regulated in the body?

The ASA protein is regulated at the gene expression level, where various regulatory factors influence its production and activity.

Can alterations in ASA gene expression affect the urea cycle?

Yes, alterations in ASA gene expression can disrupt the urea cycle and result in the buildup of argininosuccinate, leading to argininosuccinic aciduria.

Is the ASA protein associated with any diseases or conditions?

Yes, mutations or deficiencies in the ASA protein are associated with argininosuccinic aciduria, a rare inherited metabolic disorder characterized by the inability to properly metabolize argininosuccinate.

Can argininosuccinic aciduria be diagnosed through genetic tests?

Yes, genetic tests can identify mutations in the ASA gene, confirming a diagnosis of argininosuccinic aciduria and providing information for proper management and treatment.