Active Native Sheep COX1 protein

• Cat.No.: COX1-31S
• Product Overview: Native Sheep COX1 protein

Specification

• Description: COX-1 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is involved in the homeostatic role of eicosanoids and constitutively expressed in almost all animal tissues. Has an apparent KM of 8.3 μM for arachidonic acid.
• Species: Sheep
• Form: Solution in 80 mM Tris-HCl, pH 8, with 0.1% TWEEN® 20 and 300 μM diethyldithiocarbamate.
• Bio-activity: > 30,000 units/mg
• Molecular Mass: dimer subunit mol wt 70 kDa
• Unit Definition: One unit consumes one nanomole of oxygen per minute at 37 centigrade in 0.1 M Tris-HCl buffer, pH 8, containing 100 μM arachidonate, 5 mM EDTA, 2 mM phenol, and 1 μM hematin.
• Storage: Store at −70 centigrade
• Shipping: dry ice

Gene Information

• Gene Name: COX1 cytochrome c oxidase subunit I [ Ovis aries ]
• Official Symbol: COX1
• Synonyms: COI; cytochrome c oxidase subunit I
• Gene ID: 808251
• Protein Refseq: NP_008408
• UniProt ID: O78749
• Pathway: Alzheimer's disease, organism-specific biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem